Research Projects Directory

Research Projects Directory

1,637 active projects

This information was updated 5/28/2022

The Research Projects Directory includes information about all projects that currently exist in the Researcher Workbench to help provide transparency about how the Workbench is being used. Each project specifies whether Registered Tier or Controlled Tier data are used.

Note: Researcher Workbench users provide information about their research projects independently. Views expressed in the Research Projects Directory belong to the relevant users and do not necessarily represent those of the All of Us Research Program. Information in the Research Projects Directory is also cross-posted on AllofUs.nih.gov in compliance with the 21st Century Cures Act.

2 projects have 'paradox' in the project title
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Examining the Hispanic Epidemiological Paradox in All of Us

Despite having predominantly lower income and education levels, Hispanics in the United States often have better health outcomes across a range of conditions compared to the outcomes of non-Hispanic whites (NHWs). This phenomenon is commonly referred to as the Hispanic…

Scientific Questions Being Studied

Despite having predominantly lower income and education levels, Hispanics in the United States often have better health outcomes across a range of conditions compared to the outcomes of non-Hispanic whites (NHWs). This phenomenon is commonly referred to as the Hispanic Epidemiological Paradox. The purpose of this project is to explore the All of Us Research dataset to determine if there is support for the Hispanic Epidemiological Paradox within this cohort of participants. We aim to determine whether US born Hispanics have a higher prevalence of specific medical conditions compared to those of NHWs the United States.

Project Purpose(s)

  • Population Health

Scientific Approaches

The development and analyses will utilize electronic health record domains and survey question data from the All of Us Research dataset. Data will first be examined from within the Hispanic cohort of participants on various conditions and then strategically compared to the same record set of NHWs. All of Us is unique in that it allows data to be tested from a very large cohort of Hispanics (n= ~53,000) with less limitations.

Anticipated Findings

We expect to find evidence of the Hispanic Epidemiological Paradox within the participants of All of Us. We expect that despite having a predominantly lower socioeconomic status, Hispanics will have a more favorable outcome of disease and lower prevalence of chronic health conditions compared to those of non-Hispanic whites in the United States.

Demographic Categories of Interest

  • Race / Ethnicity

Data Set Used

Registered Tier

Research Team

Owner:

Evidence of the Latino Epidemiologic Paradox in the All of Us Research Project

The overall goal of this project is to examine whether there is evidence of the Latino Epidemiological Paradox within the All of Us Research Project (AoURP) cohort. We will address the following aims: • Specific Aim #1. To determine whether…

Scientific Questions Being Studied

The overall goal of this project is to examine whether there is evidence of the Latino Epidemiological Paradox within the All of Us Research Project (AoURP) cohort. We will address the following aims:
• Specific Aim #1. To determine whether Latinos have higher prevalence of gender stratified age-adjusted diabetes and obesity (overall) versus NHWs and non-Hispanic blacks in the cohort
• Specific Aim #2: To extent possible examine differences by Latino subgroups and among foreign born versus US born Latinos.

Project Purpose(s)

  • Disease Focused Research (Diabetes mellitus and obesity)
  • Population Health

Scientific Approaches

Study population. All of Us Research Project core participants. We will examine data from different data sources including electronic health records (EHR) and participant provided information (PPI) and physical measurements.

Main outcome variables: we will work with the DRC Research Support Team to obtain support for their existing classification scheme for common complex diseases which in this project would include Diabetes mellitus (Type 2) and obesity. For the definition of diseases we will use EHR data to preserve very objective outcomes, excluding for now survey data.

Statistical analysis
We will present all data stratified by gender and age adjusted using direct standardization. BMI categories would be <25, 25-30, 30-35 and >35). For diabetes AIC data will be categorized (AIC <7, AIC 7-9 and AIC > 9).

Anticipated Findings

To determine whether there is evidence of the Latino epidemiological paradox in the AoURP cohort. We expect to find evidence of the Latino Epidemiological Paradox within the All of Us Research Project (AoURP) cohort. We expect to find that despite multiple social and economic disadvantages, overall on many measures of population health Latinos seem to have a more favorable health advantage than other racial/ethnic minority groups such as blacks and in some measures even better health status than Non-Hispanic Whites (NHWs).

Previous studies like the Study of Latinos (SOL), which is the largest study of Latinos (16,000), aimed to examine this paradox but had the limitation that only included Latinos and thus comparative data on non-Latinos was not collected. With 40,000 Latinos core participants in the AllofUs study (as well 160,000 non Latinos), the AoURP study is uniquely positioned to contribute our knowledge and further understanding of this paradox.

Demographic Categories of Interest

  • Race / Ethnicity

Data Set Used

Registered Tier

Research Team

Owner:

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You can request that the All of Us Resource Access Board (RAB) review a research purpose description if you have concerns that this research project may stigmatize All of Us participants or violate the Data User Code of Conduct in some other way. To request a review, you must fill in a form, which you can access by selecting ‘request a review’ below.