Research Projects Directory

Research Projects Directory

2,583 active projects

This information was updated 9/26/2022

The Research Projects Directory includes information about all projects that currently exist in the Researcher Workbench to help provide transparency about how the Workbench is being used. Each project specifies whether Registered Tier or Controlled Tier data are used.

Note: Researcher Workbench users provide information about their research projects independently. Views expressed in the Research Projects Directory belong to the relevant users and do not necessarily represent those of the All of Us Research Program. Information in the Research Projects Directory is also cross-posted on AllofUs.nih.gov in compliance with the 21st Century Cures Act.

1 project has 'Dementia-Hypertension-Diabetes-2' in the project title
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Duplicate of Dementia-Hypertension-Diabetes-2_DatasetV3

Alzheimer’s disease is a neurodegenerative condition characterized by a progressive decline in cognitive function (dementia). Studies suggest that patients with elevated blood pressure (hypertension) are at risk of Alzheimer’s disease type dementias. High blood sugar levels or Type2 Diabetes Mellitus…

Scientific Questions Being Studied

Alzheimer’s disease is a neurodegenerative condition characterized by a progressive decline in cognitive function (dementia). Studies suggest that patients with elevated blood pressure (hypertension) are at risk of Alzheimer’s disease type dementias. High blood sugar levels or Type2 Diabetes Mellitus may also be associated with an increased risk of dementia. Some minority populations may have an increased incidence of hypertension and diabetes. For example, African Americans have a higher incidence of hypertension. Therefore we will to investigate the grouping of racial and ethnic categories, with respect to the incidence of hypertension, diabetes and dementia, to determine whether minority groups have a stronger association between dementia and co-morbidities by race/ ethnicity.
The goal of this demonstration project is to validate previous research showing potential interactions between dementia, diabetes, and hypertension, with an explicit consideration of race/ ethnicity.

Project Purpose(s)

  • Disease Focused Research (dementia)
  • Methods Development
  • Other Purpose (This work is the result of an All of Us Research Program Demonstration Project. Demonstration Projects are efforts by the All of Us Research Program designed to meet the goal of ensuring the quality and utility of the Research Hub as a resource for accelerating precision medicine. This work has been approved, reviewed, and overseen by the All of Us Research Program Science Committee and Data and Research Center to ensure compliance with program policy.)

Scientific Approaches

Data from participants (aged 40 or over) will be subjected to statistical analysis to identify interactions between the incidence of dementia, Diabetes, and Hypertension, and self-identified Race/ Ethnicity. We will only analyze participants in this age group, because the incidence of dementia is very low in patients younger than 40. We will only analyze patients with electronic health care data, because we have to ensure that patients have not had a diagnosis of hypertension, dementia or diabetes.

The statistical analysis package R will be used to create contingency tables, perform chi-squared and Cochran-Mantel-Haenszel tests. Figures will be created in R.

Anticipated Findings

We expect that our data will confirm an increased rate of dementia in African Americans with hypertension and diabetes, compared to white participants. We will determine whether other minorities also see a difference in incidence of dementia, hypertension diabetes and interactions between the them.

If there is an increased incidence of dementia in people with hypertension or diabetes, this may suggest that populations with these disorders need more careful monitoring of their conditions, as they may increase the chance of developing dementia. potentially future All of Us projects may be able to determine whether long term control of hypertension (or Diabetes/ blood glucose) may reduce the potential for developing dementia.

Demographic Categories of Interest

  • Race / Ethnicity

Data Set Used

Registered Tier

Research Team

Owner:

  • Robert Meller - Mid-career Tenured Researcher, Morehouse School of Medicine

Collaborators:

  • Shashwat Deepali Nagar - Graduate Trainee, Georgia Institute of Technology
  • Roxana Loperena Cortes - Other, All of Us Program Operational Use
  • Francis Ratsimbazafy - Other, All of Us Program Operational Use
  • King Jordan - Mid-career Tenured Researcher, Georgia Institute of Technology
  • Kelsey Mayo - Other, All of Us Program Operational Use
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