Research Projects Directory

Research Projects Directory

10,536 active projects

This information was updated 4/24/2024

The Research Projects Directory includes information about all projects that currently exist in the Researcher Workbench to help provide transparency about how the Workbench is being used. Each project specifies whether Registered Tier or Controlled Tier data are used.

Note: Researcher Workbench users provide information about their research projects independently. Views expressed in the Research Projects Directory belong to the relevant users and do not necessarily represent those of the All of Us Research Program. Information in the Research Projects Directory is also cross-posted on AllofUs.nih.gov in compliance with the 21st Century Cures Act.

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2 projects have 'Association of Cholesterol with Heart Diseases' in the project title
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Duplicate of Association of Cholesterol with Heart Diseases

The lipid hypothesis was based on an initial evidence that cardiac diseases are associated with high total cholesterol. This hypothesis has significantly changed our lifestyle during the last half century although many contradictory studies exist. Has the association between heart…

Scientific Questions Being Studied

The lipid hypothesis was based on an initial evidence that cardiac diseases are associated with high total cholesterol. This hypothesis has significantly changed our lifestyle during the last half century although many contradictory studies exist. Has the association between heart diseases and cholesterol changes during this long period? Or, is the original association result still valid now? And, is there another association mechanism that can explain the major contradictions? A re-evaluation of the association is necessary. AllOfUs provides a much larger EHR datasets for this association study than the original datasets that had only a few thousands of patients.

Project Purpose(s)

  • Disease Focused Research (myocardial infarction, stroke)

Scientific Approaches

Standard quantitative association approach and the datasets for patients with cholesterol measurements will be used.

Anticipated Findings

We expect to find changes on the association between cholesterol and heart diseases, and new association mechanism may also be found.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Data Set Used

Registered Tier

Research Team

Owner:

  • Jason Karnes - Early Career Tenure-track Researcher, University of Arizona

Collaborators:

  • Kiana Martinez - Research Fellow, University of Arizona
  • Anthony Vicenti - Project Personnel, University of Arizona
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Association of Cholesterol with Heart Diseases

The lipid hypothesis was based on an initial evidence that cardiac diseases are associated with high total cholesterol. This hypothesis has significantly changed our lifestyle during the last half century although many contradictory studies exist. Has the association between heart…

Scientific Questions Being Studied

The lipid hypothesis was based on an initial evidence that cardiac diseases are associated with high total cholesterol. This hypothesis has significantly changed our lifestyle during the last half century although many contradictory studies exist. Has the association between heart diseases and cholesterol changes during this long period? Or, is the original association result still valid now? And, is there another association mechanism that can explain the major contradictions? A re-evaluation of the association is necessary. AllOfUs provides a much larger EHR datasets for this association study than the original datasets that had only a few thousands of patients.

Project Purpose(s)

  • Disease Focused Research (myocardial infarction, stroke)

Scientific Approaches

Standard quantitative association approach and the datasets for patients with cholesterol measurements will be used.

Anticipated Findings

We expect to find changes on the association between cholesterol and heart diseases, and new association mechanism may also be found.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Data Set Used

Registered Tier

Research Team

Owner:

Collaborators:

  • Lina Sulieman - Other, All of Us Program Operational Use
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