Graduate Trainee, Broad Institute
1 active project
Arrhythmias and clonal hematopoiesis of indeterminate potential
Scientific Questions Being Studied
Clonal hematopoiesis of indeterminate potential (CHIP) is the age-related expansion of hematopoietic stem cells with acquired mutations in leukemia-associated genes, affecting >10% of individuals over 70 years old. Previous work has shown that CHIP is associated with cardiovascular disease, including coronary artery disease, heart failure, stroke, and peripheral artery disease. However, it remains unclear whether CHIP is associated with a heightened risk of developing arrhythmias. In this study, we aim to test whether CHIP is associated with arrhythmias, including supraventricular arrhythmias, bradyarrhythmias, and supraventricular arrhythmias. As CHIP-directed therapeutics are starting to emerge, and as CHIP screening tools are becoming more accessible and more widely available, understanding the relationship between CHIP and arrhythmias could provide insights into the pathogenesis of these conditions and identify new targets for precision therapeutics and prevention strategies.
- Disease Focused Research (heart disease)
We will use data from All of Us and the UK Biobank to test whether CHIP is associated with prevalent and/or incident arrhythmias. The arrhythmia phenotype we will test includes a composite of supraventricular arrhythmias, ventricular arrhythmias, and bradyarrhythmias. Secondary analyses will test the association of CHIP with individual arrhythmia groups, as well as those of gene-specific CHIP subtypes with prevalent and/or incident arrhythmias.
We hypothesize that participants with CHIP - especially those with large CHIP clones - will be at an increased risk for arrhythmias. This finding would add to the growing body of evidence linking CHIP with cardiovascular diseases, and would enhance our understanding of the relationship between CHIP and cardiovascular disease. This could provide insights into the pathogenesis of arrhythmias and identify new targets for precision therapeutics and prevention.
Demographic Categories of Interest
This study will not center on underrepresented populations.
Data Set UsedControlled Tier
- Art Schuermans - Graduate Trainee, Broad Institute
- Md Mesbah Uddin - Research Fellow, Broad Institute
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