Hui YU
Project Personnel, University of Miami
4 active projects
Chung-Autoimmune
Scientific Questions Being Studied
We are interested in two immunological diseases: arthritis and lupus. At the beginning, we'll find out if there are a considerable number of participants in AoU that have the diagnosis of either disease.
Project Purpose(s)
- Disease Focused Research (arthritis and lupus)
Scientific Approaches
Classic statistic tests and some genomic-level bioinformatics approaches. We'll utilize the SNP profiling data to make some genetic inferences.
Anticipated Findings
If we can make any interesting discoveries, the results may eventually translate to clinical practices to help with diagnosis, intervention, and prognostic prediction of patients plagued with these annoying diseases.
Demographic Categories of Interest
- Race / Ethnicity
Data Set Used
Controlled Tier
Duplicate of How to Work with All of Us Genomic Data (Hail - Plink)(v7)
Scientific Questions Being Studied
Not applicable - these notebooks demonstrate example analysis how to use Hail and PLINK to perform genome-wide association studies using the All of Us genomic data and phenotypic data.
Project Purpose(s)
- Other Purpose ((Copied to) Demonstrate to the All of Us Researcher Workbench users how to get started with the All of Us genomic data and tools. It includes an overview of all the All of Us genomic data and shows some simple examples on how to use these data.)
Scientific Approaches
Not applicable - these notebooks demonstrate example analysis how to use Hail and PLINK to perform genome-wide association studies using the All of Us genomic data and phenotypic data.
Anticipated Findings
Not applicable - these notebooks demonstrate example analysis how to use Hail and PLINK to perform genome-wide association studies using the All of Us genomic data and phenotypic data.
Demographic Categories of Interest
This study will not center on underrepresented populations.
Data Set Used
Controlled TierPCa SDOH & Prognostic genomics
Scientific Questions Being Studied
We aim to identify demographical variables that are associated with the incidence rate and treatment choice of prostate cancer in All of Us participants. Further, we will compare the genetic landscape (GWAS) between prostate subjects and non-prostate subjects.
Project Purpose(s)
- Disease Focused Research (prostate cancer)
Scientific Approaches
For the demographics survey part, we'll apply standard statistical tests such as ANOVA, t-test, and Mann-Whitney U as appropriate. For the GWAS part, we'll apply state-of-the-art bioinformatics approaches with necessary adaption towards our specific research goals.
Anticipated Findings
We would like to see if any demographical variable other than age will show significance association with prostate cancer incidence or treatment choice.
Demographic Categories of Interest
- Race / Ethnicity
- Sexual Orientation
- Disability Status
- Access to Care
- Education Level
- Income Level
Data Set Used
Controlled TierDuplicate of How to Work with All of Us Survey Data (v6)
Scientific Questions Being Studied
We recommend that all researchers explore the notebooks in this workspace to learn the basics of All of Us Program Data.
What should you expect?
By running the notebooks in this workspace, you should get familiar with how to query PPI questions/surveys, what the frequencies of answers for each question in each PPI module are.
Project Purpose(s)
- Educational
- Methods Development
- Other Purpose (This is an All of Us Tutorial Workspace created by the Researcher Workbench Support team. It is meant to provide instruction for key Researcher Workbench components and All of Us data representation.)
Scientific Approaches
By running the notebooks in this workspace, you should get familiar with how to query PPI questions/surveys, what the frequencies of answers for each question in each PPI module are.
Anticipated Findings
By reading and running the notebooks in this Tutorial Workspace, researchers will learn the following:
- how to query the survey data,
- how to summarize PPI modules, and questions.
Demographic Categories of Interest
This study will not center on underrepresented populations.
Data Set Used
Registered TierRequest a Review of this Research Project
You can request that the All of Us Resource Access Board (RAB) review a research purpose description if you have concerns that this research project may stigmatize All of Us participants or violate the Data User Code of Conduct in some other way. To request a review, you must fill in a form, which you can access by selecting ‘request a review’ below.
