Steven Tobochnik

Mass General Brigham

1 active project

Exploratory analysis of SUDEP biomarkers

This exploratory analysis aims to identify risk factors for sudden unexpected death in epilepsy (SUDEP) at the population scale based on epilepsy diagnosis, medical comorbidities, physical and cardiovascular health metrics, treatment history, and genetic data.

Scientific Questions Being Studied

This exploratory analysis aims to identify risk factors for sudden unexpected death in epilepsy (SUDEP) at the population scale based on epilepsy diagnosis, medical comorbidities, physical and cardiovascular health metrics, treatment history, and genetic data.

Project Purpose(s)

  • Disease Focused Research (Epilepsy)

Scientific Approaches

This study will incorporate data from the EHR, Genomics, Physical Measurements, Fitbit, and Survey (Personal Medical History and Family Health History) datasets. We will employ large scale cluster analysis and mixed effects linear models to investigate the association of known SUDEP risk factors with novel putative risk factors of cardiovascular health and mortality.

Anticipated Findings

We anticipate that clinical and genetic biomarkers of cardiovascular health will vary among people with epilepsy, which may serve to stratify SUDEP risk. These multi-domain models are necessary to facilitate preventive treatment strategies.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Data Set Used

Controlled Tier

Research Team

Owner:

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