1 active project
Scientific Questions Being Studied
At this time, we are only exploring the data at this stage to formalize a specific research question.
The research question we hope to answer using the data is whether we can improve interpretation of cross-disease genetic variation via mapping of trans-disease genomic variants in All of Us with platelet transcriptomic information with functional signatures in platelet gene expression, splicing, and gene fusions.
- Disease Focused Research (cancer and chronic inflammatory diseases)
- Drug Development
- Control Set
Our approaches are still in development - but in general, our objective is to identify and map trans-disease genomic variants derived from the platelet transcriptome with functional signatures in platelet gene expression, splicing, and gene fusions.
Accurate clinical interpretation of genetic variation is critical to achieving the aims of personalized medicine: determining clinical risks, and tailoring treatments to the needs of specific patients. This project will impact public health by providing clinically useful strategies derived from integrating patient genetic and clinical modifiers with functional genomic information (RNA sequencing) from adequately-powered multi-disease cohorts and a versatile yet understudied cell type, blood platelets.
Findings will enable improved interpretation of cross-disease genetic variation and further personalized prediction of clinically relevant traits and disease risks.
Demographic Categories of Interest
This study will not center on underrepresented populations.
Data Set UsedControlled Tier
- Anandi Krishnan - Other, Stanford University
You can request that the All of Us Resource Access Board (RAB) review a research purpose description if you have concerns that this research project may stigmatize All of Us participants or violate the Data User Code of Conduct in some other way. To request a review, you must fill in a form, which you can access by selecting ‘request a review’ below.