Leigh Anne Tang

Graduate Trainee, Vanderbilt University

3 active projects

Survival Analysis Fall 2021 Project (DME)

Our research question is whether blood pressure after the development of diabetic retinopathy (DR) impacts the risk for diabetic macular edema (DME). DME is a particularly severe clinical outcome among individuals with DR. We would additionally like to see if this…

Scientific Questions Being Studied

Our research question is whether blood pressure after the development of diabetic retinopathy (DR) impacts the risk for diabetic macular edema (DME). DME is a particularly severe clinical outcome among individuals with DR. We would additionally like to see if this effect varies by time, because this may inform a potential clinical intervention.

Project Purpose(s)

  • Disease Focused Research (diabetic macular edema)
  • Educational

Scientific Approaches

We plan on using traditional Cox regression and adding time-dependent covariates as becomes appropriate. We have conducted a preliminary analysis using local EHR data and are hoping to replicate that study in AOU.

Anticipated Findings

We hypothesize that hypertension is associated with an increased risk of developing DME among patients with a diabetic retinopathy. Our study will contribute to the ongoing discussions about whether hypertension is a risk factor for DME.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Research Team

Owner:

Duplicate of AMIA Genomics Walkthrough

This workspace is intended to provide basic instruction for using genomics data in All of Us, including cohort identification, covariate extraction, analysis, and display of results.

Scientific Questions Being Studied

This workspace is intended to provide basic instruction for using genomics data in All of Us, including cohort identification, covariate extraction, analysis, and display of results.

Project Purpose(s)

  • Educational

Scientific Approaches

We use OMOP, the cohort builder, and Hail for genomics analysis. The approach will be a simple rule based algorithm along with some open access genomic data to simulate a GWAS.

Anticipated Findings

We do not anticipate any findings as the analysis will not be real. Therefore this will not contribute to scientific knowledge, but hopefully will contribute to individual user's knowledge.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Research Team

Owner:

BMIF 7391

I am exploring this data as part of a graduate course on clinical and translational biomedical informatics. Currently, we are learning about existing tools for cohort building. The AOU workbench provides a unique opportunity to gain hands-on experience working with…

Scientific Questions Being Studied

I am exploring this data as part of a graduate course on clinical and translational biomedical informatics. Currently, we are learning about existing tools for cohort building. The AOU workbench provides a unique opportunity to gain hands-on experience working with a cohort building tool.

Project Purpose(s)

  • Educational

Scientific Approaches

I will use the workbench to explore the different tools, processes, and data available.

Anticipated Findings

I am hoping to learn about the design and implementation of this workbench and how these factors might promote collaboration and innovation in the future.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Research Team

Owner:

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