Christina Jordan

Early Career Tenure-track Researcher, University of Mississippi Medical Center

3 active projects

Hypertension

Hypertension in biomedically underserved populations to determine links to inflammatory conditions and heart disease.

Scientific Questions Being Studied

Hypertension in biomedically underserved populations to determine links to inflammatory conditions and heart disease.

Project Purpose(s)

  • Disease Focused Research (Hypertension)
  • Population Health

Scientific Approaches

Hypertension in biomedically underserved populations to determine links to inflammatory conditions and heart disease.

Anticipated Findings

Hypertension in biomedically underserved populations to determine links to inflammatory conditions and heart disease.

Demographic Categories of Interest

  • Race / Ethnicity
  • Sex at Birth
  • Gender Identity
  • Sexual Orientation
  • Geography
  • Education Level
  • Income Level

Research Team

Owner:

  • Christina Jordan - Early Career Tenure-track Researcher, University of Mississippi Medical Center

Bipolar Disorder - Health Disparities

Bipolar disorder (BD) is a psychiatric disorder characterized by recurrent episodes of depression and mania (BP type I) or hypomania (BP type II). BD has a lifetime prevalence of roughly 2.5% with BP II slightly more common than BP I…

Scientific Questions Being Studied

Bipolar disorder (BD) is a psychiatric disorder characterized by recurrent episodes of depression and mania (BP type I) or hypomania (BP type II). BD has a lifetime prevalence of roughly 2.5% with BP II slightly more common than BP I and females slightly more likely than males to be diagnosed (Kessler et al. 2012). Evidence from family and twin studies have established a genetic basis for BD, with more recent work suggesting that approximately 30% of heritability is due to common genetic variants . Existing GWAS studies of bipolar disorder have identified 30 loci associated with the disease, however almost the entirety of these studies were performed in individuals of European descent. The dearth of racial and ethnic minority populations in genetic studies is a significant problem that further excludes these populations from medical advances. In the present work, we aim to increase diversity and statistical power in bipolar genetic research.

Project Purpose(s)

  • Disease Focused Research (Bipolar Disorder)
  • Population Health
  • Ancestry

Scientific Approaches

The primary goal for the this project is to facilitate genetic association studies (genome-wide) of bipolar disorder generally as well as specific features of bipolar disorder including age-of-onset, extent and features of mania/hypomania and depression, frequency of cycling, and presence of psychotic symptoms. Studies may also investigate response to pharmacotherapies (e.g. lithium) and comorbidities. A primary focus of this effort is to investigate similarities and differences in the genetic and biological underpinnings of bipolar disorder across racial groups and ethnicities. Previous research has suggested racial and ethnic differences in diagnosis, presence of specific features, and treatment. One aim of this effort is to develop the tools necessary for determining whether these observed differences are biological or social in origin. These studies have direct implications for eliminating health disparities in minority populations.

Anticipated Findings

Given the high rates of misdiagnosis in minority populations we anticipate higher levels of genetic heterogeneity when investigating the bipolar phenotype. There are also reports of differential rates of manic and psychotic symptoms, as well as medication use. This may reflect the effects of misdiagnosis or it may represent legitimate differential illness presentation. If the latter, then we would anticipate this to be reflected in GWAS studies. These efforts will help to better understand the role of structural racism and systematic bias in mental health (specifically surrounding bipolar disorder) and to understand the genetic basis of bipolar disorder with regards to racial/ethnic heterogeneity.

Demographic Categories of Interest

  • Race / Ethnicity

Research Team

Owner:

  • Eric Vallender - Mid-career Tenured Researcher, University of Mississippi Medical Center
  • Christina Jordan - Early Career Tenure-track Researcher, University of Mississippi Medical Center

Physical Measurements + Cancer

I am exploring the data to determine if correlations exist between physical measurements and cancer diagnosis. If so, I hope to determine how exercise may improve cancer outcomes.

Scientific Questions Being Studied

I am exploring the data to determine if correlations exist between physical measurements and cancer diagnosis. If so, I hope to determine how exercise may improve cancer outcomes.

Project Purpose(s)

  • Other Purpose (Data is proposed to be used for preliminary data analysis.)

Scientific Approaches

My scientific approach includes:
1) Data exploration of obesity physical measurements (waist circumference, BMI, etc.) and cancer diagnosis type (breast, colon, cervical, etc.),
2) Analysis to observe correlations,
3) Additional analysis to determine differences in treatments within group correlations.

Anticipated Findings

I hope to determine how increasing physical activity improves cancer prognosis by observing changes in physical measurements and cancer treatments over time. Considering minority populations are disproportionately afflicted by cancer, this research seeks to reduce cancer health disparities in underrepresented biomedical research populations by improving cancer outcomes and reducing disease burden while promoting physical activity.

Demographic Categories of Interest

  • Race / Ethnicity
  • Age
  • Sex at Birth
  • Gender Identity
  • Sexual Orientation
  • Geography
  • Access to Care
  • Education Level
  • Income Level

Research Team

Owner:

  • Christina Jordan - Early Career Tenure-track Researcher, University of Mississippi Medical Center
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