Sandra Sanchez-Roige

Early Career Tenure-track Researcher, University of California, San Diego

1 active project

Meta-analysis of tobacco use disorders and associations with health outcomes

Tobacco use disorders (TUD) are the most prevalent substance use disorder in the US, with a high proportion of smokers meeting criteria for dependence. These individuals often have difficulty quitting, experience withdrawal symptoms, and continue smoking despite negative mental, social,…

Scientific Questions Being Studied

Tobacco use disorders (TUD) are the most prevalent substance use disorder in the US, with a high proportion of smokers meeting criteria for dependence. These individuals often have difficulty quitting, experience withdrawal symptoms, and continue smoking despite negative mental, social, and medical consequences. Genetic factors influence smoking behaviors and strides have been made in understanding aspects of tobacco initiation and use via genome-wide association studies (GWAS). However existing GWAS of TUD and nicotine-related traits have small sample sizes and focus on individuals of European ancestry. We performed a cross-ancestral meta-analysis of TUD in 740,361 individuals of European, African American, and Latin American ancestries and hope to replicate some of the main findings using All of Us, and evaluate what are the social and medical outcomes associated with genetic liability to TUD.

Project Purpose(s)

  • Disease Focused Research (tobacco use disorders)
  • Ancestry

Scientific Approaches

We will perform genetic associations of loci implicated in our study in the AllOfUs dataset using REGINIE, accounting for relevant covariates and principal components of genetic ancestry. We will test associations with smoking traits as well as other comorbid traits.

Anticipated Findings

This work will furthers our biological understanding of TUD and its shared genetic risk with other mental and physical traits, and establish EHR as useful sources of phenotypic information for studying the genetics of TUD.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Data Set Used

Controlled Tier

Research Team

Owner:

  • Sandra Sanchez-Roige - Early Career Tenure-track Researcher, University of California, San Diego
  • Gordon Ye - Undergraduate Student, University of California, San Diego
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