Margaret Sunitha Selvaraj
Research Fellow, Broad Institute
8 active projects
AOU_PAD_for_Alyssa
Scientific Questions Being Studied
We would like to conduct Genome wide association studies (GWAS) on PAD case and control data. Individual PAD GWAS will be meta analyzed to identify important loci associated with PAD. We will conduct GWAS using Regenie an meta analyze the results using Metal.
Project Purpose(s)
- Disease Focused Research (peripheral artery disease)
- Ancestry
Scientific Approaches
We will curate PAD case and controls and we will conduct GWAS using Regenie an meta analyze the results using Metal.
Anticipated Findings
We aim to meta-analyse the data with other cohorts and plan to identify new loci associated with PAD
Demographic Categories of Interest
This study will not center on underrepresented populations.
Data Set Used
Controlled TierResearch Team
Owner:
- Margaret Sunitha Selvaraj - Research Fellow, Broad Institute
- Alyssa Monica Flores - Research Fellow, Broad Institute
LipidsAOUdata_Collaboration_Workspace
Scientific Questions Being Studied
The purpose of this work space is to curate lipids from AOU data and analyze the aggregate association for certain variant sets.
Project Purpose(s)
- Ancestry
Scientific Approaches
We plan to use AOU alpha3 genomic data to aggregate to defined variant sets based on prior knowledge and test its association to lipids.
Anticipated Findings
The anticipated findings include replicating the lipid findings from other cohorts in AOU WGS data by implementing rare variant aggregate tests.
Demographic Categories of Interest
This study will not center on underrepresented populations.
Data Set Used
Controlled TierResearch Team
Owner:
- Margaret Sunitha Selvaraj - Research Fellow, Broad Institute
Collaborators:
- Rohan Bhukar - Project Personnel, Broad Institute
Duplicate of AOU_PAD_forLeland_03.31.2023
Scientific Questions Being Studied
We would like to conduct Genome wide association studies (GWAS) on PAD case and control data. Individual PAD GWAS will be meta analyzed to identify important loci associated with PAD. We will conduct GWAS using Regenie an meta analyze the results using Metal.
Project Purpose(s)
- Disease Focused Research (peripheral artery disease)
- Ancestry
Scientific Approaches
We will curate PAD case and controls and we will conduct GWAS using Regenie an meta analyze the results using Metal.
Anticipated Findings
We aim to meta-analyse the data with other cohorts and plan to identify new loci associated with PAD
Demographic Categories of Interest
This study will not center on underrepresented populations.
Data Set Used
Controlled TierResearch Team
Owner:
- Margaret Sunitha Selvaraj - Research Fellow, Broad Institute
- Leland Hull - Early Career Tenure-track Researcher, Mass General Brigham
AOU_PAD
Scientific Questions Being Studied
We would like to conduct Genome wide association studies (GWAS) on PAD case and control data. Individual PAD GWAS will be meta analyzed to identify important loci associated with PAD. We will conduct GWAS using Regenie an meta analyze the results using Metal.
Project Purpose(s)
- Disease Focused Research (peripheral artery disease)
- Ancestry
Scientific Approaches
We will curate PAD case and controls and we will conduct GWAS using Regenie an meta analyze the results using Metal.
Anticipated Findings
We aim to meta-analyse the data with other cohorts and plan to identify new loci associated with PAD
Demographic Categories of Interest
This study will not center on underrepresented populations.
Data Set Used
Controlled TierResearch Team
Owner:
- Margaret Sunitha Selvaraj - Research Fellow, Broad Institute
Collaborators:
- Buu Truong - Research Fellow, Broad Institute
LipidsAOUdata
Scientific Questions Being Studied
The purpose of this work space is to curate lipids from AOU data and analyze the aggregate association for certain variant sets.
Project Purpose(s)
- Ancestry
Scientific Approaches
We plan to use AOU alpha3 genomic data to aggregate to defined variant sets based on prior knowledge and test its association to lipids.
Anticipated Findings
The anticipated findings include replicating the lipid findings from other cohorts in AOU WGS data by implementing rare variant aggregate tests.
Demographic Categories of Interest
This study will not center on underrepresented populations.
Data Set Used
Controlled TierAOU_Hail_to_Bgen
Scientific Questions Being Studied
We would like to conduct Genome wide association studies (GWAS) on PAD case and control data. Individual PAD GWAS will be meta analyzed to identify important loci associated with PAD. We will conduct GWAS using Regenie an meta analyze the results using Metal.
Project Purpose(s)
- Disease Focused Research (peripheral artery disease)
- Ancestry
Scientific Approaches
We will curate PAD case and controls and we will conduct GWAS using Regenie an meta analyze the results using Metal.
Anticipated Findings
We aim to meta-analyse the data with other cohorts and plan to identify new loci associated with PAD
Demographic Categories of Interest
This study will not center on underrepresented populations.
Data Set Used
Controlled TierAOU_DATAPROD_CLUSTER
Scientific Questions Being Studied
We would like to conduct Genome wide association studies (GWAS) on PAD case and control data. Individual PAD GWAS will be meta analyzed to identify important loci associated with PAD. We will conduct GWAS using Regenie an meta analyze the results using Metal.
Project Purpose(s)
- Disease Focused Research (peripheral artery disease)
- Ancestry
Scientific Approaches
We will curate PAD case and controls and we will conduct GWAS using Regenie an meta analyze the results using Metal.
Anticipated Findings
We aim to meta-analyse the data with other cohorts and plan to identify new loci associated with PAD
Demographic Categories of Interest
This study will not center on underrepresented populations.
Data Set Used
Controlled TierResearch Team
Owner:
- Margaret Sunitha Selvaraj - Research Fellow, Broad Institute
Collaborators:
- Henry Condon - Project Personnel, All of Us Program Operational Use
- Buu Truong - Research Fellow, Broad Institute
OGTT
Scientific Questions Being Studied
We are planning to investigate how genetic variation is associated with impaired glucose response after an oral glucose tolerance test.
Project Purpose(s)
- Disease Focused Research (impaired glucose tolerance)
- Ancestry
Scientific Approaches
We are planning to use genetic and phenotypic information. We will use two h glucose as the outcome variable. We will use genetic data to identify genetic variants associated with two h glucose after accounting for age, sex, and BMI. We will conduct analyses stratified by genetically-derived ethnicity.
Anticipated Findings
This study will help us identify genetic variants associated with impaired glucose response. These results could shed light on molecular processes underlying dysglycemia and inform future studies to investigate whether genetic susceptibility to impaired glucose could be attenuated by specific lifestyle or dietary modifications.
Demographic Categories of Interest
- Race / Ethnicity
- Age
- Sex at Birth
- Gender Identity
- Sexual Orientation
- Geography
- Access to Care
- Education Level
- Income Level
Data Set Used
Controlled TierResearch Team
Owner:
- Margaret Sunitha Selvaraj - Research Fellow, Broad Institute
- Jordi Merino - Research Fellow, Mass General Brigham
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