Jennifer Odoi
Graduate Trainee, University of Texas Medical Branch (UTMB) at Galveston
1 active project
Disparity in Uterine Cancer II
Scientific Questions Being Studied
When comparing non-Hispanic Black women with uterine cancer, what are differences between the groups with good outcomes (early stage at diagnosis, survival at 3 and 5 years) vs. poor outcomes (stage 3+ at diagnosis, mortality at 3 and 5 years)? What are the modifiable risk factors in the group with poor outcomes? Could knowledge of these differences be utilized in an educational program to help decrease the disparities in outcomes?
Project Purpose(s)
- Population Health
Scientific Approaches
We plan to conduct a chart review with the following inclusion and exclusion criteria. Inclusion criteria include the following: 1. Age greater than or equal to 18 years 2. Black race 3. Diagnosis of endometrial and/or uterine cancer Exclusion criteria include the following: 1. Concurrent breast or color or other primary cancer 2. Immunosuppressive disease Records will be collected based on the following filters: 1. Age, sex 2. Diagnosis The following data will be collected from each record. 1. Age, sex 2. Race, ethnicity 3. Tumor type 4. Tumor stage 5. Treatment 6. Age at menopause 7. Age at menarche 8. G’/P’s 9. Hormonal contraception 10. Fibroids 11. BMI, dx of obesity 12. Metabolic syndrome 13. Tobacco use 14. Diabetes, HTN 15. Hx polyps 16. Hx post-menopausal bleeding 17. Hx menorrhagia 18. Hx metrorrhagia 19. Family hx – CA, hysterectomy 20. Socioeconomic – insurance/access to medical care 21. Hx of assault or domestic violence
Anticipated Findings
We anticipate that there will be both modifiable and non-modifiable risk factors associated with a poor prognosis. For example, we expect that women who have had irregular or heavy menstrual cycles, barriers to accessing medical care, history of assault or domestic violence, and comorbidities, such as metabolic syndrome and hypertension, will have poorer outcomes (higher stage at diagnosis, lower survival rate at 3 or 5 years). We expect that programs geared towards modifiable risk factors and that educate women about expectations during menopause and perimenopause may reduce delay to diagnosis and increase early stage diagnosis of cancer, and potentially lead to better outcomes. Most studies compare between racial groups. There is a paucity of literature on comparisons within women of the same race with good vs. poor prognosis.
Demographic Categories of Interest
- Race / Ethnicity
Data Set Used
Registered TierResearch Team
Owner:
- Jennifer Odoi - Graduate Trainee, University of Texas Medical Branch (UTMB) at Galveston
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