Graduate Trainee, University of Texas Medical Branch (UTMB) at Galveston
1 active project
Disparity in Uterine Cancer
Scientific Questions Being Studied
When comparing non-Hispanic Black women with uterine cancer, what are differences between the groups with good outcomes (early stage at diagnosis, survival at 3 and 5 years) vs. poor outcomes (stage 3+ at diagnosis, mortality at 3 and 5 years)?
What are the modifiable risk factors in the group with poor outcomes?
Could knowledge of these differences be utilized in an educational program to help decrease the disparities in outcomes?
- Disease Focused Research (uterine cancer)
- Population Health
We plan to conduct a chart review with the following inclusion and exclusion criteria.
Inclusion criteria include the following:
1. Age greater than or equal to 18 years
2. Black race
3. Diagnosis of endometrial and/or uterine cancer
Exclusion criteria include the following:
1. Concurrent breast or color or other primary cancer
2. Immunosuppressive disease
Records will be collected based on the following filters:
1. Age, sex
The following data will be collected from each record.
1. Age, sex
2. Race, ethnicity
3. Tumor type
4. Tumor stage
6. Age at menopause
7. Age at menarche
9. Hormonal contraception
11. BMI, dx of obesity
12. Metabolic syndrome
13. Tobacco use
14. Diabetes, HTN
15. Hx polyps
16. Hx post-menopausal bleeding
17. Hx menorrhagia
18. Hx metrorrhagia
19. Family hx – CA, hysterectomy
20. Socioeconomic – insurance/access to medical care
21. Hx of assault or domestic violence
We anticipate that there will be both modifiable and non-modifiable risk factors associated with a poor prognosis. For example, we expect that women who have had irregular or heavy menstrual cycles, barriers to accessing medical care, history of assault or domestic violence, and comorbidities, such as metabolic syndrome and hypertension, will have poorer outcomes (higher stage at diagnosis, lower survival rate at 3 or 5 years).
We expect that programs geared towards modifiable risk factors and that educate women about expectations during menopause and perimenopause may reduce delay to diagnosis and increase early stage diagnosis of cancer, and potentially lead to better outcomes.
Most studies compare between racial groups. There is a paucity of literature on comparisons within women of the same race with good vs. poor prognosis.
Demographic Categories of Interest
- Race / Ethnicity
Data Set UsedRegistered Tier
- Jennifer Odoi - Graduate Trainee, University of Texas Medical Branch (UTMB) at Galveston
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