Catherine Gimbrone

Graduate Trainee, Columbia University

1 active project

Genetics, social environment, and depression research

I intend to study the effect of the interaction between polygenic risk scores and the social environment on depression and other health related outcomes. This is an important question because, while this association has been explored previously, it has not…

Scientific Questions Being Studied

I intend to study the effect of the interaction between polygenic risk scores and the social environment on depression and other health related outcomes. This is an important question because, while this association has been explored previously, it has not been explored in such a broad and inclusive dataset.

Project Purpose(s)

  • Disease Focused Research (mental depression)
  • Population Health
  • Social / Behavioral
  • Ancestry

Scientific Approaches

I plan to first use descriptive statistics to determine the prevalence and distribution of polygenic risk scores and depression within the whole sample and key sociodemographic subgroups. I will then use regression methods to predict the effect of polygenic risk scores on depression, dependent on changes in the social environment.

Anticipated Findings

I hope to better understand the relationship between polygenic risk scores and depression in a diverse population. I believe that this study will enhance current scientific knowledge within the field and improve understandings of potential risk factors for depression.

Demographic Categories of Interest

  • Race / Ethnicity
  • Sex at Birth
  • Gender Identity
  • Sexual Orientation
  • Geography
  • Access to Care
  • Education Level
  • Income Level

Data Set Used

Controlled Tier

Research Team

Owner:

1 - 1 of 1
<
>
Request a Review of this Research Project

You can request that the All of Us Resource Access Board (RAB) review a research purpose description if you have concerns that this research project may stigmatize All of Us participants or violate the Data User Code of Conduct in some other way. To request a review, you must fill in a form, which you can access by selecting ‘request a review’ below.