Catherine Gimbrone
Graduate Trainee, Columbia University
2 active projects
OLDER Genetics, social environment, and depression research
Scientific Questions Being Studied
I intend to study the effects of the interaction between polygenic risk scores and the social environment on depression and other health-related outcomes. Further, I plan to explore whether my findings are generalizable to other observed populations. These questions are important because, while this association has been assessed previously, it has not been addressed using such a broad and inclusive dataset from which findings may be generalizable to often overlooked subpopulations.
Project Purpose(s)
- Disease Focused Research (mental depression)
- Population Health
- Social / Behavioral
- Methods Development
- Ancestry
Scientific Approaches
I plan to first use descriptive statistics to determine the prevalence and distribution of polygenic risk scores and depression within the whole sample and key sociodemographic subgroups. I will then use regression methods to predict the effect of polygenic risk scores on depression, dependent on changes in the social environment. Next, I will use transportability methods in conjunction with an external sample to assess the generalizability of my findings.
Anticipated Findings
I hope to better understand the relationship between polygenic risk scores and depression in a diverse population. I believe that this study will enhance current scientific knowledge within the field and improve understandings of potential risk factors for depression.
Demographic Categories of Interest
- Race / Ethnicity
- Sex at Birth
- Gender Identity
- Sexual Orientation
- Geography
- Access to Care
- Education Level
- Income Level
Data Set Used
Controlled TierResearch Team
Owner:
- Catherine Gimbrone - Graduate Trainee, Columbia University
Collaborators:
- Jun Qian - Other, All of Us Program Operational Use
v7 Genetics, social environment, and depression research
Scientific Questions Being Studied
I intend to study the effects of the interaction between polygenic risk scores and the social environment on depression and other health-related outcomes. Further, I plan to explore whether my findings are generalizable to other observed populations. These questions are important because, while this association has been assessed previously, it has not been addressed using such a broad and inclusive dataset from which findings may be generalizable to often overlooked subpopulations.
Project Purpose(s)
- Disease Focused Research (mental depression)
- Population Health
- Social / Behavioral
- Methods Development
- Ancestry
Scientific Approaches
I plan to first use descriptive statistics to determine the prevalence and distribution of polygenic risk scores and depression within the whole sample and key sociodemographic subgroups. I will then use regression methods to predict the effect of polygenic risk scores on depression, dependent on changes in the social environment. Next, I will use transportability methods in conjunction with an external sample to assess the generalizability of my findings.
Anticipated Findings
I hope to better understand the relationship between polygenic risk scores and depression in a diverse population. I believe that this study will enhance current scientific knowledge within the field and improve understandings of potential risk factors for depression.
Demographic Categories of Interest
- Race / Ethnicity
- Sex at Birth
- Gender Identity
- Sexual Orientation
- Geography
- Access to Care
- Education Level
- Income Level
Data Set Used
Controlled TierRequest a Review of this Research Project
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