Yebin Kim

Graduate Trainee, Indiana University

1 active project

Multiallelic Genes Investigation

1. How are the variants on multiallelic genes such as CYP gene and phenotypes related? 2. Are there novel major allele types in multiallelic genes which have not been defined yet?

Scientific Questions Being Studied

1. How are the variants on multiallelic genes such as CYP gene and phenotypes related?
2. Are there novel major allele types in multiallelic genes which have not been defined yet?

Project Purpose(s)

  • Methods Development
  • Ancestry

Scientific Approaches

Our research will be based on the PheWAS study. We'll search for phenotypes associated with specific genes across the range of thousands of human phenotypes. Instead of studying on SNVs, we're going to see the association between phenotypes and multiallelic variants.

For finding novel allele types, we're going to apply multiple genotyping software tools such as Cyrius or Aldy4.

Anticipated Findings

We aim to understand the relationship between mutations in specific multiallelic genes and phenotypes. Even though lots of associations between genes and traits have been disclosed, not enough investigations of multiallelic variants have been conducted due to the complexities of multiallelic genes. So we hope to try various statistical and computational methods to analyze multiallelic genes and reveal their impacts on diseases. Also, finding new major allele types will allow researchers to define broader populations' allele types and suggest possibilities for further investigation.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Data Set Used

Controlled Tier

Research Team

Owner:

  • Yebin Kim - Graduate Trainee, Indiana University

Collaborators:

  • Genevieve Mortensen - Graduate Trainee, Indiana University
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