Bonnie Huang
Graduate Trainee, Northwestern University
5 active projects
Alcohol and Glaucoma (V7)
Scientific Questions Being Studied
Scientific research question: How does alcohol affect glaucoma prevalence, risk, and severity?
Why this is important: There has been contradicting evidence on how alcohol affects glaucoma. Research has shown acute alcohol consumption reduces intraocular pressure while the evidence for chronic consumption is unclear. Our study hopes to better elucidate how alcohol affects glaucoma, which deserves particular attention given the high prevalence of alcohol consumption and the danger of glaucoma.
Project Purpose(s)
- Disease Focused Research (Glaucoma)
Scientific Approaches
The datasets that we will be using are mainly: alcohol data, primary open-angle glaucoma data, and genetic data. Research methods: we will analyze any association between alcohol and glaucoma outcomes, detect whether there is a dose-response relationship to this association, if any, and whether genetics modulate the association. Guided statistics will be used to answer our research questions.
Anticipated Findings
Given the conflicting evidence regarding alcohol use on glaucoma, the anticipated findings are hard to predict. This highlights the importance of our project, as All of Us provides a large and diverse participant pool for us to better validate existing literature findings on alcohol and glaucoma.
Demographic Categories of Interest
This study will not center on underrepresented populations.
Data Set Used
Controlled TierResearch Team
Owner:
- Jo-Hsuan Wu - Research Fellow, University of California, San Diego
- Leo Li Tang Meller - Graduate Trainee, University of California, San Diego
- Sally Baxter - Research Fellow, University of California, San Diego
- Kiana Tavakoli - Research Fellow, University of California, San Diego
- Bharanidharan Radha Saseendrakumar - Project Personnel, University of California, San Diego
- Bonnie Huang - Graduate Trainee, Northwestern University
Alcohol and Glaucoma
Scientific Questions Being Studied
Scientific research question: How does alcohol affect glaucoma prevalence, risk, and severity?
Why this is important: There has been contradicting evidence on how alcohol affects glaucoma. Research has shown acute alcohol consumption reduces intraocular pressure while the evidence for chronic consumption is unclear. Our study hopes to better elucidate how alcohol affects glaucoma, which deserves particular attention given the high prevalence of alcohol consumption and the danger of glaucoma.
Project Purpose(s)
- Disease Focused Research (Glaucoma)
Scientific Approaches
The datasets that we will be using are mainly: alcohol data, primary open-angle glaucoma data, and genetic data. Research methods: we will analyze any association between alcohol and glaucoma outcomes, detect whether there is a dose-response relationship to this association, if any, and whether genetics modulate the association. Guided statistics will be used to answer our research questions.
Anticipated Findings
Given the conflicting evidence regarding alcohol use on glaucoma, the anticipated findings are hard to predict. This highlights the importance of our project, as All of Us provides a large and diverse participant pool for us to better validate existing literature findings on alcohol and glaucoma.
Demographic Categories of Interest
This study will not center on underrepresented populations.
Data Set Used
Controlled TierResearch Team
Owner:
- Jo-Hsuan Wu - Research Fellow, University of California, San Diego
- Leo Li Tang Meller - Graduate Trainee, University of California, San Diego
- Sally Baxter - Research Fellow, University of California, San Diego
- Kiana Tavakoli - Research Fellow, University of California, San Diego
- Bharanidharan Radha Saseendrakumar - Project Personnel, University of California, San Diego
- Bonnie Huang - Graduate Trainee, Northwestern University
Genetics and Glaucoma
Scientific Questions Being Studied
We are studying genomic variation in glaucoma and would like to use the AllofUs dataset to validate prior GWASes. This question is important because a lot of studies have been performed on populations of European descent, but it is important to look at genetic variation in non-European populations as well. AllofUs has a diverse enrollment, which is perfect for this study.
Project Purpose(s)
- Disease Focused Research (Glaucoma)
- Ancestry
Scientific Approaches
For this study, we plan on performing a GWAS to identify variants associated with glaucoma in the AllofUs dataset. For cases, we plan on including patients with POAG diagnosis codes and surgical codes and genomic data, while the control cohort would consist of adults with genomic data but without POAG. Tools we plan on using include HAIL in accordance with the All of Us example notebooks to perform the GWAS. Data visualization methods will include Manhattan plots, QQ plots, and identification of significant genetic variants associated with glaucoma.
Anticipated Findings
Using the AllofUs dataset, which contains data from diverse populations, we are hoping to validate previous GWAS results that have mostly been performed on European populations. Our findings would contribute by identifying genetic variants associated with glaucoma in non-European populations. Furthermore, in the future we also hope to use these results to study the relative contribution of genetic variation versus social determinants to glaucoma.
Demographic Categories of Interest
- Race / Ethnicity
Data Set Used
Controlled TierResearch Team
Owner:
- Sally Baxter - Research Fellow, University of California, San Diego
- Bonnie Huang - Graduate Trainee, Northwestern University
Impact of SDoH on Glaucoma Interventions
Scientific Questions Being Studied
Questions we intend to study include
A) Among newly diagnosed ocular hypertensive or glaucoma patients, whether social determinants impact or influence the likelihood of pressure lowering after medical/laser intervention
B) Whether social determinants play a role in a patients having various surgical procedures or how many medications they use
C) Whether patients require additional glaucoma surgery after minimally invasive glaucoma surgery
These questions are important because they will help us better understand the interplay between social determinants of health and different glaucoma interventions.
Project Purpose(s)
- Disease Focused Research (Glaucoma)
- Social / Behavioral
- Drug Development
Scientific Approaches
We intend to study patients with glaucoma who are on medication therapy or underwent surgery . Then, we plan to use logistic regression to study the impact of social determinants of health and the likelihood of having different surgical procedures.
Anticipated Findings
We anticipate to find that different social determinants of health (e.g. literacy, education, discrimination) impact the type of surgical intervention glaucoma patients receive. This will help the scientific community better understand how non-medical factors impact glaucoma treatment.
Demographic Categories of Interest
- Race / Ethnicity
- Disability Status
- Access to Care
- Education Level
- Income Level
Data Set Used
Controlled TierDR Barriers to Care by Race/Ethnicity
Scientific Questions Being Studied
We intend to study among patients with diabetic retinopathy, whether certain racial/ethnic groups report significantly greater barriers to care. This question is important for improving access to care for patients with diabetic retinopathy.
Project Purpose(s)
- Population Health
- Social / Behavioral
Scientific Approaches
We intend to study patients with diabetic retinopathy who participated in the health care access and utilization survey or the social determinants of health survey. Then, we plan to use logistic regression to study barriers to care among different races.
Anticipated Findings
We anticipate to find that certain barriers to care are increased among certain minority populations, which would contribute to knowledge in the field about how different barriers to care differ among different racial/ethnic groups.
Demographic Categories of Interest
- Race / Ethnicity
- Access to Care
- Education Level
- Income Level
Data Set Used
Controlled TierResearch Team
Owner:
- Bonnie Huang - Graduate Trainee, Northwestern University
Collaborators:
- Sally Baxter - Research Fellow, University of California, San Diego
- Bharanidharan Radha Saseendrakumar - Project Personnel, University of California, San Diego
Request a Review of this Research Project
You can request that the All of Us Resource Access Board (RAB) review a research purpose description if you have concerns that this research project may stigmatize All of Us participants or violate the Data User Code of Conduct in some other way. To request a review, you must fill in a form, which you can access by selecting ‘request a review’ below.
