Shu-Yi Liao

Senior Researcher, National Jewish Health

1 active project

Shared genetic features of sarcoidosis and other inflammatory disease

Some of the sarcoidosis may progress to fibrotic sarcoidosis, but the etiologies are not fully understood. Sarcoidosis may share some genetic features with other fibrotic lung diseases secondary to autoimmune diseases such as rheumatoid arthritis or scleroderma.

Scientific Questions Being Studied

Some of the sarcoidosis may progress to fibrotic sarcoidosis, but the etiologies are not fully understood. Sarcoidosis may share some genetic features with other fibrotic lung diseases secondary to autoimmune diseases such as rheumatoid arthritis or scleroderma.

Project Purpose(s)

  • Ancestry

Scientific Approaches

We hypothesize that there are shared fibrotic/inflammatory genetic features between sarcoidosis and autoimmune interstitial lung diseases and that a subset of shared genetic features will be associated with fibrotic sarcoidosis. We will identify those shared features using the pre-existing genome-wide databases, including All of US Research Program and UK Biobank.

Anticipated Findings

Our findings will facilitate future biomarker development and potential fibrotic sarcoidosis treatment implications.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Data Set Used

Controlled Tier

Research Team

Owner:

  • Shu-Yi Liao - Senior Researcher, National Jewish Health
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