Graduate Trainee, Emory University
1 active project
AFib epidemiology (AOU v4)
Scientific Questions Being Studied
The overall goal of this study, as a Demonstration project, is to evaluate the ability of the All of Us Research Program data to replicate epidemiologic patterns of atrial fibrillation (AF), a common arrhythmia, previously described in other setting. We will address this goal with these two aims:
• Specific Aim 1. To determine the association of race and ethnicity with the prevalence and incidence of atrial fibrillation (AF). We hypothesize than non-whites will have lower prevalence and incidence of AF than whites.
• Specific Aim 2. To estimate associations of established risk factors for AF with the prevalence and incidence of AF. We hypothesize that increased body mass index, higher blood pressure, diabetes, smoking and a prior history of cardiovascular diseases will be associated with increased prevalence and incidence of AF.
- Population Health
- Other Purpose (This work is a result of an All of Us Research Program Demonstration Project. The projects are efforts by the Program designed to meet the program's goal of ensuring the quality and utility of the Research Hub as a resource for accelerating discovery in science and medicine. This work was reviewed and overseen by the All of Us Research Program Science Committee and the Data and Research Center to ensure compliance with program policy, including policies for acceptable data access and use.)
We will select all All of Us participants who self-reported sex at birth male or female, whose self-reported race was white, black or Asian, as well as those who self-reported being Hispanics.
Atrial fibrillation (AF) will be identified from self-reports in the medical survey or from electronic health records (EHR).
Clinical factors will be identified from EHR and study measurements (blood pressure, weight, height).
We will evaluate the association of demographic (age, sex, race/ethnicity) and clinical (body mass index, blood pressure, smoking, cardiovascular diseases) factors with prevalence of self-reported AF and prevalence of AF in the EHR, as well as incident AF ascertained from the EHR.
The overall goal of this project is to evaluate the prevalence and incidence of atrial fibrillation (AF), overall and by race/ethnicity, as well as to confirm the association of established risk factors for AF in the All of Us Research participants. We expect to confirm associations between demographic and clinical variables previously reported in the literature, demonstrating the value of the All of Us Research Program data to address questions regarding this common cardiovascular disease.
Demographic Categories of Interest
- Race / Ethnicity
Data Set UsedRegistered Tier
- Peter Buto - Graduate Trainee, Emory University
- Christopher Lord - Project Personnel, All of Us Program Operational Use
- Alvaro Alonso - Late Career Tenured Researcher, Emory University
- Vignesh Subbian - Early Career Tenure-track Researcher, University of Arizona
- Francis Ratsimbazafy - Other, All of Us Program Operational Use
- Aymone Kouame - Other, All of Us Program Operational Use
- Aniqa Alam
- Konstantinos Sidiropoulos - Other, Nova Southeastern University
You can request that the All of Us Resource Access Board (RAB) review a research purpose description if you have concerns that this research project may stigmatize All of Us participants or violate the Data User Code of Conduct in some other way. To request a review, you must fill in a form, which you can access by selecting ‘request a review’ below.