Frida Kleiman
Project Personnel, City University of New York (CUNY)
1 active project
CDKN1A/p21 SNP
Scientific Questions Being Studied
We would like to identify participant traits, demographic, race, age, gender, and medical conditions of carriers of the single nucleotide polymorphism (SNP) in the CDKN1A gene participants with the same demographic, race, age, gender carrying the wild-type allele.
CDKN1A is the gene that codes for p21, a tumor suppressor protein with diverse cellular functions. We are also interested in any changes in gene sequence.
Project Purpose(s)
- Disease Focused Research (cancer, muscular dystrophy, kidney disease, or other clinical conditions)
- Population Health
- Drug Development
- Ancestry
Scientific Approaches
We will use well established scientific protocols. We will analyze how changes affect p21 protein expression in downstream functional effects, such as DNA replication, DNA repair, activation of cell-cycle checkpoints and cellular fate in cell-death, senescence or proliferation. Scientific rigor assurances: Data from 3 independent biological experiments will be analyzed by triplicate. Data with P values * (≤0.05) or ** (≤0.005) will be considered. Two-Sample t-Test assuming equal variances will be used to compare samples. An alpha level of 0.05 will be used for all statistical tests.
Anticipated Findings
Understanding the complex interplay between mutations and proteins that regulate growth and cell viability, such as CDKN1A/p21, might help us in identifying mechanisms that drive tumor progression, relapse, and treatment resistance. The data obtained from the All of Us database will enable us to correlate how SNP associate with participants' traits, demographic, race, age, gender, and medical conditions. This study might help to predict clinical outcome disparities in minority groups , such as participants with African and Latin American ancestry, related with p21 tumor suppressor expression.
Demographic Categories of Interest
- Race / Ethnicity
Data Set Used
Registered TierResearch Team
Owner:
- Frida Kleiman - Project Personnel, City University of New York (CUNY)
Collaborators:
- Shayaa Muhammad - Project Personnel, City University of New York (CUNY)
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