Kiana Tavakoli
Research Fellow, University of California, San Diego
3 active projects
Calcium channel blocker and Glaucoma
Scientific Questions Being Studied
We look at the patients who used calcium channel blockers(CCB) and analyze if it affects the prevalence or progression of primary open-angle glaucoma(POAG) patients by using the All of Us research data set. the specific questions we will ask are:
1.what is the population of patients who use CCBrand have/ have not POAG?
2. What is the effect of using CCB on POAG people? is it increase the prevalence or progression of POAG?
3. What other factors will CCB affect that affect the POAG people too?
4. What is the effect of CCB on Glaucoma?
5. What is the reason for the change in glaucoma prevalence and progression by using CCB?
6 What is the effect of other Blood pressure medication on POAG?
we hypothesized that using the CCB may cause the increased prevalence and progression of Glaucoma in POAG patients. This study will give a better understanding of blood pressure medication's effect on Glaucoma.
Project Purpose(s)
- Educational
Scientific Approaches
We use All of the US data sets for people who have POAG and using CCB and are more than 40 years old. We will use R to analyze the data with the t-test and chi-square test, and use multivariant and single variant models with logistic regression. First, describe the characteristic data of our population and analyze characteristic data (Sex, Race, Ethnicity, Age,...). Second, we analyze with the t-test and chi-square test between the patient who uses/does not CCB and has/has not POAG and calculate the p-value. Third, we analyze by using logistic and linear regression between the variables we have including the CCB, POAG, systolic and diastolic blood pressure, age, race, sex, ethnicity, lipid profile, and BMI. we will describe the effect of CCB by using the other factors on the prevalence and progression of POAG. The limitation is we don't have series eye pressure and visual field of POAG and nonPOAG people and we don't know if the patient was adherent to the CCB medication or not.
Anticipated Findings
For this study, we expected to realize the effect of systemic medication on Glaucoma. because glaucoma is the first cause of blindness in the world it is so important to find out different factors that affect glaucoma, where we can slow the progression or decrease the prevalence rate. we will find out if the dosing and duration of usage of systemic medication will affect glaucoma and we can compound it for glaucoma patients. importantly, the detailed code developed will be made available within the researcher workbench, so other researchers may more easily extract systemic medication data in glaucoma patients. we believe this study will help both ophthalmologists and internists a lot, besides it is great for glaucoma patients and public health by reducing the risk of the first cause of blindness in the world.
Demographic Categories of Interest
This study will not center on underrepresented populations.
Data Set Used
Registered TierResearch Team
Owner:
- Sally Baxter - Research Fellow, University of California, San Diego
- Kiana Tavakoli - Research Fellow, University of California, San Diego
- Bharanidharan Radha Saseendrakumar - Project Personnel, University of California, San Diego
Collaborators:
- Sophia Sidhu - Graduate Trainee, University of California, San Diego
Alcohol and Glaucoma (V7)
Scientific Questions Being Studied
Scientific research question: How does alcohol affect glaucoma prevalence, risk, and severity?
Why this is important: There has been contradicting evidence on how alcohol affects glaucoma. Research has shown acute alcohol consumption reduces intraocular pressure while the evidence for chronic consumption is unclear. Our study hopes to better elucidate how alcohol affects glaucoma, which deserves particular attention given the high prevalence of alcohol consumption and the danger of glaucoma.
Project Purpose(s)
- Disease Focused Research (Glaucoma)
Scientific Approaches
The datasets that we will be using are mainly: alcohol data, primary open-angle glaucoma data, and genetic data. Research methods: we will analyze any association between alcohol and glaucoma outcomes, detect whether there is a dose-response relationship to this association, if any, and whether genetics modulate the association. Guided statistics will be used to answer our research questions.
Anticipated Findings
Given the conflicting evidence regarding alcohol use on glaucoma, the anticipated findings are hard to predict. This highlights the importance of our project, as All of Us provides a large and diverse participant pool for us to better validate existing literature findings on alcohol and glaucoma.
Demographic Categories of Interest
This study will not center on underrepresented populations.
Data Set Used
Controlled TierResearch Team
Owner:
- Jo-Hsuan Wu - Research Fellow, University of California, San Diego
- Leo Li Tang Meller - Graduate Trainee, University of California, San Diego
- Sally Baxter - Research Fellow, University of California, San Diego
- Kiana Tavakoli - Research Fellow, University of California, San Diego
- Bharanidharan Radha Saseendrakumar - Project Personnel, University of California, San Diego
- Bonnie Huang - Graduate Trainee, Northwestern University
Alcohol and Glaucoma
Scientific Questions Being Studied
Scientific research question: How does alcohol affect glaucoma prevalence, risk, and severity?
Why this is important: There has been contradicting evidence on how alcohol affects glaucoma. Research has shown acute alcohol consumption reduces intraocular pressure while the evidence for chronic consumption is unclear. Our study hopes to better elucidate how alcohol affects glaucoma, which deserves particular attention given the high prevalence of alcohol consumption and the danger of glaucoma.
Project Purpose(s)
- Disease Focused Research (Glaucoma)
Scientific Approaches
The datasets that we will be using are mainly: alcohol data, primary open-angle glaucoma data, and genetic data. Research methods: we will analyze any association between alcohol and glaucoma outcomes, detect whether there is a dose-response relationship to this association, if any, and whether genetics modulate the association. Guided statistics will be used to answer our research questions.
Anticipated Findings
Given the conflicting evidence regarding alcohol use on glaucoma, the anticipated findings are hard to predict. This highlights the importance of our project, as All of Us provides a large and diverse participant pool for us to better validate existing literature findings on alcohol and glaucoma.
Demographic Categories of Interest
This study will not center on underrepresented populations.
Data Set Used
Controlled TierResearch Team
Owner:
- Jo-Hsuan Wu - Research Fellow, University of California, San Diego
- Leo Li Tang Meller - Graduate Trainee, University of California, San Diego
- Sally Baxter - Research Fellow, University of California, San Diego
- Kiana Tavakoli - Research Fellow, University of California, San Diego
- Bharanidharan Radha Saseendrakumar - Project Personnel, University of California, San Diego
- Bonnie Huang - Graduate Trainee, Northwestern University
Request a Review of this Research Project
You can request that the All of Us Resource Access Board (RAB) review a research purpose description if you have concerns that this research project may stigmatize All of Us participants or violate the Data User Code of Conduct in some other way. To request a review, you must fill in a form, which you can access by selecting ‘request a review’ below.
