Jose Nolazco
Research Fellow, Baylor College of Medicine
3 active projects
PCa_v7
Scientific Questions Being Studied
Prostate Adenocarcinoma (PRAD) is associated with 1 in 25 African American men deaths, compared to 1 in 45 White American men deaths. Genetic and societal factors may contribute to this racial disparity and our project aims to shed light in both factors. Our goals are to find ethnic specific risk factors using survey-based features and genetic risk factors using the genetic variants data.
Project Purpose(s)
- Disease Focused Research (prostate cancer)
- Population Health
- Educational
- Methods Development
- Ancestry
Scientific Approaches
To achieve our goals we will use statistical tests and state-of-the-art tools to compare case and control genomes in order to identify variants that appear disproportionally in cases and genes with heavy variant load in cases. Such tools include the Evolutionary Action method and the software packages EMMAX and ACAT, amongst others.
Anticipated Findings
We anticipate obtaining lists of candidate genes and their variants that drive PRAD in African American men and in White American men, which we will contrast and compare with the current knowledge (e.g. BRCA1, BRCA2, and HOXB13 genes). This work may provide new genetic targets that affect the development and progression of PRAD, especially amongst the African American men and reduce the racial disparity in genetic risk diagnosis.
Demographic Categories of Interest
- Race / Ethnicity
Data Set Used
Controlled TierResearch Team
Owner:
- Victoria Mgbemena - Early Career Tenure-track Researcher, Baylor College of Medicine
- Sabur Badmos - Research Fellow, University of Texas at El Paso
- Lesley Chapman Hannah - Research Fellow, National Cancer Institute (NIH - NCI)
- Kimiko Krieger - Research Fellow, Baylor College of Medicine
- Panagiotis Katsonis - Other, Baylor College of Medicine
- Jose Nolazco - Research Fellow, Baylor College of Medicine
- Deyana Lewis - Research Fellow, National Institutes of Health (NIH)
Collaborators:
- Jun Qian - Other, All of Us Program Operational Use
Dream_Team
Scientific Questions Being Studied
Prostate Adenocarcinoma (PRAD) is associated with 1 in 25 African American men deaths, compared to 1 in 45 White American men deaths. Genetic and societal factors may contribute to this racial disparity and our project aims to shed light in both factors. Our goals are to find ethnic specific risk factors using survey-based features and genetic risk factors using the genetic variants data.
Project Purpose(s)
- Disease Focused Research (prostate cancer)
- Population Health
- Educational
- Methods Development
- Ancestry
Scientific Approaches
To achieve our goals we will use statistical tests and state-of-the-art tools to compare case and control genomes in order to identify variants that appear disproportionally in cases and genes with heavy variant load in cases. Such tools include the Evolutionary Action method and the software packages EMMAX and ACAT, amongst others.
Anticipated Findings
We anticipate obtaining lists of candidate genes and their variants that drive PRAD in African American men and in White American men, which we will contrast and compare with the current knowledge (e.g. BRCA1, BRCA2, and HOXB13 genes). This work may provide new genetic targets that affect the development and progression of PRAD, especially amongst the African American men and reduce the racial disparity in genetic risk diagnosis.
Demographic Categories of Interest
- Race / Ethnicity
Data Set Used
Controlled TierResearch Team
Owner:
- Victoria Mgbemena - Early Career Tenure-track Researcher, Baylor College of Medicine
- Sabur Badmos - Research Fellow, University of Texas at El Paso
- Lesley Chapman Hannah - Research Fellow, National Cancer Institute (NIH - NCI)
- Kimiko Krieger - Research Fellow, Baylor College of Medicine
- Panagiotis Katsonis - Other, Baylor College of Medicine
- Jose Nolazco - Research Fellow, Baylor College of Medicine
- Deyana Lewis - Research Fellow, National Institutes of Health (NIH)
Collaborators:
- Jun Qian - Other, All of Us Program Operational Use
Smoking and Cancer
Scientific Questions Being Studied
Continued smoking in cancer patients can increase the odds ratio of recurrence and progression. Some patients will adopt a healthier lifestyle after a cancer diagnosis and quit smoking, while others will continue to smoke. Medical counseling plays a fundamental role in tobacco cessation, therefore, the tobacco cessation rate might be influenced by the healthcare professional factor. While some physicians will not get involved in this task others, might provide direct advice regarding tobacco cessation to their patients or enroll them in a program with specialized tobacco cessation experts. This study aimed to test the hypothesis that different medical specialties are associated with different tobacco cessation rates in tobacco-related cancer patients.
Project Purpose(s)
- Disease Focused Research (cancer)
- Social / Behavioral
Scientific Approaches
Cross-sectional study.
The outcome of interest was to continue to smoke.
Identify smoking prevalence among cancer survivors.
Analyze the smoking rates among different cancers by specialty.
Anticipated Findings
We hypothesize that there is a difference in continuing smoking depending on cancer type by specialty.
Scientific Contribution for physicians:
- Realize that smoking status in cancer patients depends not only on patients factors but also on physician factors
- Learn that in this large study, we found that urologic patients were the ones with the highest continuing to smoke rate after diagnosis.
- Ask themselves how are they doing tobacco cessation counseling to their patients in their practice.
- Intend to improve (hopefully, after understanding the importance of their role as physicians) tobacco cessation counseling with their patients.
Demographic Categories of Interest
This study will not center on underrepresented populations.
Data Set Used
Registered TierResearch Team
Owner:
- Jose Nolazco - Research Fellow, Baylor College of Medicine
Collaborators:
- Panagiotis Katsonis - Other, Baylor College of Medicine
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