Inas Aboobakar

Research Fellow, Mass General Brigham

1 active project

Mitochondrial gene variants, smoking and glaucoma risk

We are interested in better understanding how genetic factors and environmental influences contribute to the development of primary open-angle glaucoma, in hopes of using this information to develop precision medicine approaches to disease diagnosis, risk stratification and treatment.

Scientific Questions Being Studied

We are interested in better understanding how genetic factors and environmental influences contribute to the development of primary open-angle glaucoma, in hopes of using this information to develop precision medicine approaches to disease diagnosis, risk stratification and treatment.

Project Purpose(s)

  • Disease Focused Research (primary open angle glaucoma)
  • Ancestry

Scientific Approaches

We plan to generate genetic risk scores and polygenic risk scores to assess disease risk. We will also test the interaction of these scores with environmental risk factors to test the combined effects of the two. This will be performed in multiple, diverse datasets, including the All of Us dataset.

Anticipated Findings

We anticipate that these studies will help better understand the contributions of genetic variation, environmental risk and development of primary open angle glaucoma, which will enable more targeted approaches to disease diagnosis and treatment.

Demographic Categories of Interest

  • Race / Ethnicity
  • Age

Data Set Used

Controlled Tier

Research Team

Owner:

1 - 1 of 1
<
>
Request a Review of this Research Project

You can request that the All of Us Resource Access Board (RAB) review a research purpose description if you have concerns that this research project may stigmatize All of Us participants or violate the Data User Code of Conduct in some other way. To request a review, you must fill in a form, which you can access by selecting ‘request a review’ below.