Kimiko Krieger
Research Fellow, Baylor College of Medicine
6 active projects
PCa_v7
Scientific Questions Being Studied
Prostate Adenocarcinoma (PRAD) is associated with 1 in 25 African American men deaths, compared to 1 in 45 White American men deaths. Genetic and societal factors may contribute to this racial disparity and our project aims to shed light in both factors. Our goals are to find ethnic specific risk factors using survey-based features and genetic risk factors using the genetic variants data.
Project Purpose(s)
- Disease Focused Research (prostate cancer)
- Population Health
- Educational
- Methods Development
- Ancestry
Scientific Approaches
To achieve our goals we will use statistical tests and state-of-the-art tools to compare case and control genomes in order to identify variants that appear disproportionally in cases and genes with heavy variant load in cases. Such tools include the Evolutionary Action method and the software packages EMMAX and ACAT, amongst others.
Anticipated Findings
We anticipate obtaining lists of candidate genes and their variants that drive PRAD in African American men and in White American men, which we will contrast and compare with the current knowledge (e.g. BRCA1, BRCA2, and HOXB13 genes). This work may provide new genetic targets that affect the development and progression of PRAD, especially amongst the African American men and reduce the racial disparity in genetic risk diagnosis.
Demographic Categories of Interest
- Race / Ethnicity
Data Set Used
Controlled TierResearch Team
Owner:
- Victoria Mgbemena - Early Career Tenure-track Researcher, Baylor College of Medicine
- Sabur Badmos - Research Fellow, University of Texas at El Paso
- Lesley Chapman Hannah - Research Fellow, National Cancer Institute (NIH - NCI)
- Kimiko Krieger - Research Fellow, Baylor College of Medicine
- Panagiotis Katsonis - Other, Baylor College of Medicine
- Jose Nolazco - Research Fellow, Baylor College of Medicine
- Deyana Lewis - Research Fellow, National Institutes of Health (NIH)
Collaborators:
- Jun Qian - Other, All of Us Program Operational Use
Dream_Team
Scientific Questions Being Studied
Prostate Adenocarcinoma (PRAD) is associated with 1 in 25 African American men deaths, compared to 1 in 45 White American men deaths. Genetic and societal factors may contribute to this racial disparity and our project aims to shed light in both factors. Our goals are to find ethnic specific risk factors using survey-based features and genetic risk factors using the genetic variants data.
Project Purpose(s)
- Disease Focused Research (prostate cancer)
- Population Health
- Educational
- Methods Development
- Ancestry
Scientific Approaches
To achieve our goals we will use statistical tests and state-of-the-art tools to compare case and control genomes in order to identify variants that appear disproportionally in cases and genes with heavy variant load in cases. Such tools include the Evolutionary Action method and the software packages EMMAX and ACAT, amongst others.
Anticipated Findings
We anticipate obtaining lists of candidate genes and their variants that drive PRAD in African American men and in White American men, which we will contrast and compare with the current knowledge (e.g. BRCA1, BRCA2, and HOXB13 genes). This work may provide new genetic targets that affect the development and progression of PRAD, especially amongst the African American men and reduce the racial disparity in genetic risk diagnosis.
Demographic Categories of Interest
- Race / Ethnicity
Data Set Used
Controlled TierResearch Team
Owner:
- Victoria Mgbemena - Early Career Tenure-track Researcher, Baylor College of Medicine
- Sabur Badmos - Research Fellow, University of Texas at El Paso
- Lesley Chapman Hannah - Research Fellow, National Cancer Institute (NIH - NCI)
- Kimiko Krieger - Research Fellow, Baylor College of Medicine
- Panagiotis Katsonis - Other, Baylor College of Medicine
- Jose Nolazco - Research Fellow, Baylor College of Medicine
- Deyana Lewis - Research Fellow, National Institutes of Health (NIH)
Collaborators:
- Jun Qian - Other, All of Us Program Operational Use
Duplicate of Introductory example of GWAS with type 2 diabetes phenotype
Scientific Questions Being Studied
Not applicable - this workspace is intended to be an introductory example of how to do a genome-wide association study on the All of Us genomic data that individuals can easily click through and understand.
Project Purpose(s)
- Educational
Scientific Approaches
Not applicable - this workspace is intended to be an introductory example of how to do a genome-wide association study on the All of Us genomic data that individuals can easily click through and understand.
Anticipated Findings
Not applicable - this workspace is intended to be an introductory example of how to do a genome-wide association study on the All of Us genomic data that individuals can easily click through and understand.
Demographic Categories of Interest
This study will not center on underrepresented populations.
Data Set Used
Controlled TierExploring Hypertension Data Types
Scientific Questions Being Studied
Not applicable - this Workspace is intended from educational purposes at the 2022 UBR Faculty Summit to learn how to use the Researcher Workbench by analyzing a data type for hypertension.
Project Purpose(s)
- Educational
Scientific Approaches
Not applicable - this Workspace is intended from educational purposes at the 2022 UBR Faculty Summit to learn how to use the Researcher Workbench by analyzing a data type for hypertension.
Anticipated Findings
Not applicable - this Workspace is intended from educational purposes at the 2022 UBR Faculty Summit to learn how to use the Researcher Workbench by analyzing a data type for hypertension.
Demographic Categories of Interest
This study will not center on underrepresented populations.
Data Set Used
Registered TierResearch Team
Owner:
- Kimiko Krieger - Research Fellow, Baylor College of Medicine
Collaborators:
- Jordan Booker - Early Career Tenure-track Researcher, Baylor College of Medicine
Test Run of Quick Demo of Plots and Analyses
Scientific Questions Being Studied
Not applicable - this workspace is intended to be an introductory example of how to easily click-through analyses for new users to the All of Us Researcher Workbench with whom this Notebook will be shared. This workspace is adapted from the demo workspace "How to Get Started with the Registered Tier Data"
Project Purpose(s)
- Educational
- Methods Development
Scientific Approaches
Not applicable - this workspace is intended to be an introductory example of how to easily click-through analyses for new users to the All of Us Researcher Workbench with whom this Notebook will be shared. This workspace is adapted from the demo workspace "How to Get Started with the Registered Tier Data"
Anticipated Findings
Not applicable - this workspace is intended to be an introductory example of how to easily click-through analyses for new users to the All of Us Researcher Workbench with whom this Notebook will be shared. This workspace is adapted from the demo workspace "How to Get Started with the Registered Tier Data"
Demographic Categories of Interest
This study will not center on underrepresented populations.
Data Set Used
Registered TierDuplicate of Introductory example of GWAS with type 2 diabetes phenotype
Scientific Questions Being Studied
Not applicable - this workspace is intended to be an introductory example of how to do a genome-wide association study on the All of Us genomic data that individuals can easily click through and understand.
Project Purpose(s)
- Educational
Scientific Approaches
Not applicable - this workspace is intended to be an introductory example of how to do a genome-wide association study on the All of Us genomic data that individuals can easily click through and understand.
Anticipated Findings
Not applicable - this workspace is intended to be an introductory example of how to do a genome-wide association study on the All of Us genomic data that individuals can easily click through and understand.
Demographic Categories of Interest
This study will not center on underrepresented populations.
Data Set Used
Controlled TierRequest a Review of this Research Project
You can request that the All of Us Resource Access Board (RAB) review a research purpose description if you have concerns that this research project may stigmatize All of Us participants or violate the Data User Code of Conduct in some other way. To request a review, you must fill in a form, which you can access by selecting ‘request a review’ below.
