Kelly von Beck

Graduate Trainee, Vanderbilt University Medical Center

2 active projects

How are Mosaic Chromosomal Alterations Associated with Risk of Multiple Myeloma

Research question: How is the presence or absence of mosaic chromosomal alterations (mCAs) in a peripheral blood sample associated with incident diagnosis of MGUS and multiple myeloma? - Presence or absence of mCAs will provide further information on the pathogenesis…

Scientific Questions Being Studied

Research question: How is the presence or absence of mosaic chromosomal alterations (mCAs) in a peripheral blood sample associated with incident diagnosis of MGUS and multiple myeloma?
- Presence or absence of mCAs will provide further information on the pathogenesis of multiple myeloma
- In this age of precision medicine, this information will allow us to better inform patients of the risks of mCAs

Project Purpose(s)

  • Disease Focused Research (multiple myeloma)

Scientific Approaches

I plan to build a cohort of adults that do not have a diagnosis of hematologic cancer at the date of sampling. I will run the MoChA algorithm to determine mCA status. I plan to analyze the results using R.

Anticipated Findings

Anticipated findings: mCAs are associated with increased risk of incident MGUS and/or multiple myeloma
- Provide a better understanding of the pathogenesis and identification of patients who may need to be screened for MGUS

Demographic Categories of Interest

This study will not center on underrepresented populations.

Data Set Used

Controlled Tier

Research Team

Owner:

  • Kelly von Beck - Graduate Trainee, Vanderbilt University Medical Center

Collaborators:

  • Troy von Beck - Graduate Trainee, Emory University

How are Mosaic Chromosomal Alterations Associated with Risk of Multiple Myeloma

Research question: How is the presence or absence of mosaic chromosomal alterations (mCAs) in a peripheral blood sample associated with incident diagnosis of MGUS and multiple myeloma? - Presence or absence of mCAs will provide further information on the pathogenesis…

Scientific Questions Being Studied

Research question: How is the presence or absence of mosaic chromosomal alterations (mCAs) in a peripheral blood sample associated with incident diagnosis of MGUS and multiple myeloma?
- Presence or absence of mCAs will provide further information on the pathogenesis of multiple myeloma
- In this age of precision medicine, this information will allow us to better inform patients of the risks of mCAs

Project Purpose(s)

  • Disease Focused Research (multiple myeloma)

Scientific Approaches

I plan to build a cohort of adults that do not have a diagnosis of hematologic cancer at the date of sampling. I will run the MoChA algorithm to determine mCA status. I plan to analyze the results using R.

Anticipated Findings

Anticipated findings: mCAs are associated with increased risk of incident MGUS and/or multiple myeloma
- Provide a better understanding of the pathogenesis and identification of patients who may need to be screened for MGUS

Demographic Categories of Interest

This study will not center on underrepresented populations.

Data Set Used

Controlled Tier

Research Team

Owner:

  • Kelly von Beck - Graduate Trainee, Vanderbilt University Medical Center

Collaborators:

  • Troy von Beck - Graduate Trainee, Emory University
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