Taralynn Mack

Graduate Trainee, Vanderbilt University

2 active projects

Clonal Hematopoiesis in All of Us Genomes

With age, our blood stem cells acquire mutations. Most of these mutations are inconsequential, but some cause the blood stem cells to expand, a process known as clonal hematopoiesis. In this study, we seek to identify clonal hematopoiesis in the…

Scientific Questions Being Studied

With age, our blood stem cells acquire mutations. Most of these mutations are inconsequential, but some cause the blood stem cells to expand, a process known as clonal hematopoiesis. In this study, we seek to identify clonal hematopoiesis in the All of Us Research participant partners to understand the spectrum of clonal hematopoiesis, its causes and consequences.

Project Purpose(s)

  • Ancestry

Scientific Approaches

We plan to identify clonal hematopoiesis from all of us genomic data. This will be done using Mutect2 somatic mutation caller applied to the genome sequencing data and other algorithms applied to the array genotyping data.

Anticipated Findings

We expect that this will expand our understanding of the spectrum of mutations in clonal hematopoiesis in diverse populations.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Data Set Used

Controlled Tier

Research Team

Owner:

  • Taralynn Mack - Graduate Trainee, Vanderbilt University
  • Henry Condon - Project Personnel, All of Us Program Operational Use
  • Caitlyn Vlasschaert - Graduate Trainee, Vanderbilt University Medical Center
  • Brian Sharber - Project Personnel, Vanderbilt University Medical Center
  • Alexander Bick - Early Career Tenure-track Researcher, Vanderbilt University Medical Center

Collaborators:

  • Yash Pershad - Graduate Trainee, Vanderbilt University Medical Center
  • Jun Qian - Other, All of Us Program Operational Use
  • Christopher Lord - Project Personnel, All of Us Program Operational Use
  • Brandy Mapes - Other, All of Us Program Operational Use
  • Varun Gupta - Project Personnel, Albert Einstein College of Medicine
  • Quanhu Sheng - Early Career Tenure-track Researcher, Vanderbilt University Medical Center
  • LaShaunta Glover - Teacher/Instructor/Professor, Duke University
  • Brice Laurent - Undergraduate Student, Harvard Medical School
  • Brian Johnson - Graduate Trainee, University of California, San Diego
  • Alex Silver - Graduate Trainee, Vanderbilt University Medical Center

Using REGENIE with dsub in All of Us

This workspace is intended to show researchers how to run REGENIE to perform a GWAS on All of Us whole genome data for educational purposes.

Scientific Questions Being Studied

This workspace is intended to show researchers how to run REGENIE to perform a GWAS on All of Us whole genome data for educational purposes.

Project Purpose(s)

  • Educational

Scientific Approaches

We will show how to use the whole genome datasets (in bgen format) to perform a GWAS. In the tutorial, we use PLINK to filter the genetic data and REGENIE to run the GWAS itself.

Anticipated Findings

This educational workspace will provide the framework for researchers to perform their own GWAS on their phenotype of interest within their own workspaces.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Data Set Used

Controlled Tier

Research Team

Owner:

  • Taralynn Mack - Graduate Trainee, Vanderbilt University
  • Alexander Bick - Early Career Tenure-track Researcher, Vanderbilt University Medical Center

Collaborators:

  • Jun Qian - Other, All of Us Program Operational Use
  • Jennifer Zhang - Project Personnel, All of Us Program Operational Use
  • Hannah Poisner - Graduate Trainee, Vanderbilt University
  • Nicole Deflaux - Other, All of Us Program Operational Use
  • Brian Sharber - Project Personnel, Vanderbilt University Medical Center
  • Margaret Sunitha Selvaraj - Research Fellow, Broad Institute
  • Laura Raffield - Other, University of North Carolina, Chapel Hill
  • Nikita Pozdeyev - Early Career Tenure-track Researcher, University of Colorado, Denver
  • Kelsy Alaine Broadaway - Project Personnel, University of North Carolina, Chapel Hill
  • Henry Condon - Project Personnel, All of Us Program Operational Use
  • Bjoernar Tuftin - Project Personnel, University of North Carolina, Chapel Hill
  • Aaron Eisman - Graduate Trainee, Brown University
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