Leo Li Tang Meller
Graduate Trainee, University of California, San Diego
3 active projects
Tinnitus and Cognition V7
Scientific Questions Being Studied
Tinnitus is a common condition that frequently coexists with hearing loss in the aging population. Hearing loss is a high-risk factor for cognitive decline. Compared with hearing loss, the effect of tinnitus on cognition is unclear and is often confounded by uncontrolled factors including hearing loss.
The objective of this study is to investigate the association between tinnitus and cognition in an elderly population with and without hearing loss while considering other covariates.
Research questions:
What is the association between Tinnitus and Cognition?
Project Purpose(s)
- Disease Focused Research (Dementia)
Scientific Approaches
Multivariable linear and binary logistic regression will be used to assess the association between tinnitus (exposure) and cognition (outcome) in normal hearing vs. hearing loss while adjusting for covariates.
Anticipated Findings
The present study will delineate the tinnitus role in cognition, among different hearing statuses, after controlling for age, sex, race, education, and physical wellbeing covariates. Hearing loss is a leading modifiable risk factor for dementia. Understanding how tinnitus interacts with hearing loss in this relationship will provide insights into risks, effects of treatment, and other impacts.
Demographic Categories of Interest
- Race / Ethnicity
- Age
Data Set Used
Registered TierResearch Team
Owner:
- Yasmeen Abdelkarim Mohamed Hamza - Early Career Tenure-track Researcher, Florida State University
- Leo Li Tang Meller - Graduate Trainee, University of California, San Diego
- Xianhui Wang - Research Fellow, University of California, Irvine
Collaborators:
- Fan-Gang Zeng - Late Career Tenured Researcher, University of California, Irvine
Alcohol and Glaucoma (V7)
Scientific Questions Being Studied
Scientific research question: How does alcohol affect glaucoma prevalence, risk, and severity?
Why this is important: There has been contradicting evidence on how alcohol affects glaucoma. Research has shown acute alcohol consumption reduces intraocular pressure while the evidence for chronic consumption is unclear. Our study hopes to better elucidate how alcohol affects glaucoma, which deserves particular attention given the high prevalence of alcohol consumption and the danger of glaucoma.
Project Purpose(s)
- Disease Focused Research (Glaucoma)
Scientific Approaches
The datasets that we will be using are mainly: alcohol data, primary open-angle glaucoma data, and genetic data. Research methods: we will analyze any association between alcohol and glaucoma outcomes, detect whether there is a dose-response relationship to this association, if any, and whether genetics modulate the association. Guided statistics will be used to answer our research questions.
Anticipated Findings
Given the conflicting evidence regarding alcohol use on glaucoma, the anticipated findings are hard to predict. This highlights the importance of our project, as All of Us provides a large and diverse participant pool for us to better validate existing literature findings on alcohol and glaucoma.
Demographic Categories of Interest
This study will not center on underrepresented populations.
Data Set Used
Controlled TierResearch Team
Owner:
- Jo-Hsuan Wu - Research Fellow, University of California, San Diego
- Leo Li Tang Meller - Graduate Trainee, University of California, San Diego
- Sally Baxter - Research Fellow, University of California, San Diego
- Kiana Tavakoli - Research Fellow, University of California, San Diego
- Bharanidharan Radha Saseendrakumar - Project Personnel, University of California, San Diego
- Bonnie Huang - Graduate Trainee, Northwestern University
Alcohol and Glaucoma
Scientific Questions Being Studied
Scientific research question: How does alcohol affect glaucoma prevalence, risk, and severity?
Why this is important: There has been contradicting evidence on how alcohol affects glaucoma. Research has shown acute alcohol consumption reduces intraocular pressure while the evidence for chronic consumption is unclear. Our study hopes to better elucidate how alcohol affects glaucoma, which deserves particular attention given the high prevalence of alcohol consumption and the danger of glaucoma.
Project Purpose(s)
- Disease Focused Research (Glaucoma)
Scientific Approaches
The datasets that we will be using are mainly: alcohol data, primary open-angle glaucoma data, and genetic data. Research methods: we will analyze any association between alcohol and glaucoma outcomes, detect whether there is a dose-response relationship to this association, if any, and whether genetics modulate the association. Guided statistics will be used to answer our research questions.
Anticipated Findings
Given the conflicting evidence regarding alcohol use on glaucoma, the anticipated findings are hard to predict. This highlights the importance of our project, as All of Us provides a large and diverse participant pool for us to better validate existing literature findings on alcohol and glaucoma.
Demographic Categories of Interest
This study will not center on underrepresented populations.
Data Set Used
Controlled TierResearch Team
Owner:
- Jo-Hsuan Wu - Research Fellow, University of California, San Diego
- Leo Li Tang Meller - Graduate Trainee, University of California, San Diego
- Sally Baxter - Research Fellow, University of California, San Diego
- Kiana Tavakoli - Research Fellow, University of California, San Diego
- Bharanidharan Radha Saseendrakumar - Project Personnel, University of California, San Diego
- Bonnie Huang - Graduate Trainee, Northwestern University
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