Jian Dai

Project Personnel, National Institutes of Health (NIH)

2 active projects

Multiple Sclerosis Study from Controlled Tier

Multiple Sclerosis is serious illness affecting the central nervous system which can cause disability and death. Currently, there is no cure for multiple sclerosis, and the genetic and environmental factors that lead to this disease are poorly understood. Elucidating the…

Scientific Questions Being Studied

Multiple Sclerosis is serious illness affecting the central nervous system which can cause disability and death. Currently, there is no cure for multiple sclerosis, and the genetic and environmental factors that lead to this disease are poorly understood. Elucidating the risk factors for MS may lead to better modes of prevention and more effective treatment options. We want to explore which factors are significantly associated with incidence of multiple sclerosis and determine whether changing lifestyle factors or nutritional supplements such as vitamin D can be helpful for disease prevention.

Project Purpose(s)

  • Disease Focused Research (multiple sclerosis (MS))
  • Ancestry

Scientific Approaches

Some previous reports indicated that MS incidence varies in different geographical locations. We will randomly sample subjects with or without multiple sclerosis in different geographical locations. We will also extract related information such as lifestyle factors, vitamin D supplement use, and demographic data. We hope to determine which geographical and lifestyle factors are associated with incidence of MS using statistical analysis and machine learning approaches. We will also explore if there are genomic variants related to occurrence of MS.

Anticipated Findings

We hope to discover which geographical factors are associated with increased incidence of multiple sclerosis. We also hope to identify lifestyle factors that can help mitigate that risk of MS disease in those regions.

Demographic Categories of Interest

  • Geography

Data Set Used

Controlled Tier

Research Team

Owner:

  • Jian Dai - Project Personnel, National Institutes of Health (NIH)

Collaborators:

  • Josh Denny - Other, All of Us Program Operational Use
  • Slavina Goleva - Research Fellow, National Institutes of Health (NIH)

Multiple Sclerosis (MS) Study

Multiple Sclerosis is serious illness affecting the central nervous system which can cause disability and death. Currently, there is no cure for multiple sclerosis, and the genetic and environmental factors that lead to this disease are poorly understood. Elucidating the…

Scientific Questions Being Studied

Multiple Sclerosis is serious illness affecting the central nervous system which can cause disability and death. Currently, there is no cure for multiple sclerosis, and the genetic and environmental factors that lead to this disease are poorly understood. Elucidating the risk factors for MS may lead to better modes of prevention and more effective treatment options.

We want to explore which factors are significantly associated with incidence of multiple sclerosis and, more specifically, determine whether nutritional supplements such as vitamin D can be helpful for disease prevention.

Project Purpose(s)

  • Disease Focused Research (multiple sclerosis)

Scientific Approaches

Some previous reports indicated that MS incidence varies in different geographical locations. We will randomly sample subjects with or without multiple sclerosis in different geographical locations. We will also extract related information such as lifestyle factors, vitamin D supplement use, and demographic data. We hope to determine which geographical and lifestyle factors are associated with incidence of MS using statistical analysis and machine learning approaches. We will also explore if there are genomic variants related to occurrence of MS once the data is available.

Anticipated Findings

We hope to discover which geographical factors are associated with increased incidence of multiple sclerosis. We also hope to identify lifestyle factors that can help mitigate that risk of MS disease in those regions.

Demographic Categories of Interest

  • Geography
  • Disability Status

Data Set Used

Registered Tier

Research Team

Owner:

  • Jian Dai - Project Personnel, National Institutes of Health (NIH)

Collaborators:

  • Josh Denny - Other, All of Us Program Operational Use
  • Slavina Goleva - Research Fellow, National Institutes of Health (NIH)
  • David Schlueter - Research Fellow, National Institutes of Health (NIH)
  • Ariel Williams - Research Fellow, National Institutes of Health (NIH)
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