Sophia Sidhu
Graduate Trainee, University of California, San Diego
6 active projects
Metformin and Glaucoma v7
Scientific Questions Being Studied
There remain limited treatment options for glaucoma outside lowering intraocular pressure, which is not effective in all patients. Metformin, an antihyperglycemic drug used for the management of diabetes, is being increasingly explored for its neuroprotective effects in the eye. We would like to investigate the relationship between metformin use and primary open-angle glaucoma incidence and progression using All of Us Data, given the limited studies focusing on this topic.
Project Purpose(s)
- Drug Development
Scientific Approaches
We will build a cohort of patients with diabetes aged 40 and older, with no prior glaucoma diagnosis at baseline to assess glaucoma incidence. We will build a cohort of patients with diabetes aged 40 and older with an existing diagnosis of glaucoma to assess glaucoma progression. Then we will develop concept sets and extract data on outcomes (i.e. diagnosis of glaucoma, glaucoma progression represented by need for glaucoma surgery), as well as predictors including clinical data and social data. Analyses will be performed in R notebooks within the All of Us Workbench environment.
Anticipated Findings
We anticipate that metformin use will be associated with a reduced risk of developing primary open-angle glaucoma and reduced risk of progression to glaucoma surgery.
Demographic Categories of Interest
- Race / Ethnicity
- Age
- Geography
- Disability Status
- Access to Care
- Education Level
- Income Level
Data Set Used
Registered TierResearch Team
Owner:
- Jo-Hsuan Wu - Research Fellow, University of California, San Diego
- Sophia Sidhu - Graduate Trainee, University of California, San Diego
- Sally Baxter - Research Fellow, University of California, San Diego
- Bharanidharan Radha Saseendrakumar - Project Personnel, University of California, San Diego
Collaborators:
- Varsha Varkhedi - Undergraduate Student, University of California, San Diego
- Kaela Acuff - Graduate Trainee, University of California, San Diego
- Alison Chan - Graduate Trainee, University of California, San Diego
Metformin and Glaucoma
Scientific Questions Being Studied
There remain limited treatment options for glaucoma outside lowering intraocular pressure, which is not effective in all patients. Metformin, an antihyperglycemic drug used for the management of diabetes, is being increasingly explored for its neuroprotective effects in the eye. We would like to investigate the relationship between metformin use and primary open-angle glaucoma incidence and progression using All of Us Data, given the limited studies focusing on this topic.
Project Purpose(s)
- Drug Development
Scientific Approaches
We will build a cohort of patients with diabetes aged 40 and older, with no prior glaucoma diagnosis at baseline to assess glaucoma incidence. We will build a cohort of patients with diabetes aged 40 and older with an existing diagnosis of glaucoma to assess glaucoma progression. Then we will develop concept sets and extract data on outcomes (i.e. diagnosis of glaucoma, glaucoma progression represented by need for glaucoma surgery), as well as predictors including clinical data and social data. Analyses will be performed in R notebooks within the All of Us Workbench environment.
Anticipated Findings
We anticipate that metformin use will be associated with a reduced risk of developing primary open-angle glaucoma and reduced risk of progression to glaucoma surgery.
Demographic Categories of Interest
- Race / Ethnicity
- Age
- Geography
- Disability Status
- Access to Care
- Education Level
- Income Level
Data Set Used
Registered TierResearch Team
Owner:
- Jo-Hsuan Wu - Research Fellow, University of California, San Diego
- Sophia Sidhu - Graduate Trainee, University of California, San Diego
- Sally Baxter - Research Fellow, University of California, San Diego
- Bharanidharan Radha Saseendrakumar - Project Personnel, University of California, San Diego
Collaborators:
- Varsha Varkhedi - Undergraduate Student, University of California, San Diego
- Kaela Acuff - Graduate Trainee, University of California, San Diego
- Alison Chan - Graduate Trainee, University of California, San Diego
Afib and glaucoma progression to surgery
Scientific Questions Being Studied
We are exploring the relationship between atrial fibrillation and glaucoma to determine if atrial fibrillation is a risk factor for glaucomatous progression.
Project Purpose(s)
- Disease Focused Research (Atrial fibrillation and glaucoma)
Scientific Approaches
We will likely perform multivariable logistic regression to determine whether a comorbidity (atrial fibrillation) is associated with glaucomatous progression, as defined by progression to surgery.
Anticipated Findings
Our findings would help determine whether atrial fibrillation should be considered as a risk factor for glaucomatous progression, thereby informing decision to monitor patients more closely or intervene sooner in the disease process.
Demographic Categories of Interest
This study will not center on underrepresented populations.
Data Set Used
Registered TierResearch Team
Owner:
- Varsha Varkhedi - Undergraduate Student, University of California, San Diego
- Sophia Sidhu - Graduate Trainee, University of California, San Diego
- Kaela Acuff - Graduate Trainee, University of California, San Diego
- Alison Chan - Graduate Trainee, University of California, San Diego
- Catherine Sheils - Research Fellow, University of California, San Diego
Collaborators:
- Sally Baxter - Research Fellow, University of California, San Diego
- Bharanidharan Radha Saseendrakumar - Project Personnel, University of California, San Diego
SDHA in Eye Conditions - v6 Dataset
Scientific Questions Being Studied
We are planning to explore disparities in healthcare access and utilization for patients with eye conditions across different demographic groups. We would like to evaluate risk of developing advanced/severe disease in different eye conditions, and understand how social determinants contribute to this risk while adjusting for other known risk factors. We are also interested in understanding the availability of social determinants of health data in this data repository compared to EHR clinical data warehouses alone.
Project Purpose(s)
- Population Health
Scientific Approaches
We will build cohorts of patients with various eye diseases (i.e. diabetic retinopathy, retinal vein occlusions, glaucoma, etc.). Then we will develop concept sets and extract data on outcomes (i.e. development of complications), as well as predictors including clinical data and social data. We will draw on survey data and EHR data within All of Us. When genomic data and wearable data become available, we are interested in evaluating those data sources as well. We will use statistical modeling and machine learning to generate predictive models.
Anticipated Findings
We anticipate that there may be differential risk for developing complications based on disparities in healthcare access and utilization for patients with eye conditions.
Demographic Categories of Interest
- Race / Ethnicity
- Age
- Geography
- Disability Status
- Access to Care
- Education Level
- Income Level
Data Set Used
Registered TierResearch Team
Owner:
- Varsha Varkhedi - Undergraduate Student, University of California, San Diego
- Tonya Lee - Graduate Trainee, University of California, San Diego
- Sophia Sidhu - Graduate Trainee, University of California, San Diego
- Sally Baxter - Research Fellow, University of California, San Diego
- Kaela Acuff - Graduate Trainee, University of California, San Diego
- Gordon Ye - Undergraduate Student, University of California, San Diego
- Catherine Sheils - Research Fellow, University of California, San Diego
- Bita Shahrvini - Graduate Trainee, University of California, San Diego
- Bharanidharan Radha Saseendrakumar - Project Personnel, University of California, San Diego
- Arash Delavar - Graduate Trainee, University of California, San Diego
Collaborators:
- Joy Guo - Graduate Trainee, University of California, San Diego
- Bonnie Huang - Graduate Trainee, Northwestern University
- Kiana Tavakoli - Research Fellow, University of California, San Diego
Metformin and Glaucoma v6
Scientific Questions Being Studied
There remain limited treatment options for glaucoma outside lowering intraocular pressure, which is not effective in all patients. Metformin, an antihyperglycemic drug used for the management of diabetes, is being increasingly explored for its neuroprotective effects in the eye. We would like to investigate the relationship between metformin use and primary open-angle glaucoma incidence and progression using All of Us Data, given the limited studies focusing on this topic.
Project Purpose(s)
- Drug Development
Scientific Approaches
We will build a cohort of patients with diabetes aged 40 and older, with no prior glaucoma diagnosis at baseline to assess glaucoma incidence. We will build a cohort of patients with diabetes aged 40 and older with an existing diagnosis of glaucoma to assess glaucoma progression. Then we will develop concept sets and extract data on outcomes (i.e. diagnosis of glaucoma, glaucoma progression represented by need for glaucoma surgery), as well as predictors including clinical data and social data. Analyses will be performed in R notebooks within the All of Us Workbench environment.
Anticipated Findings
We anticipate that metformin use will be associated with a reduced risk of developing primary open-angle glaucoma and reduced risk of progression to glaucoma surgery.
Demographic Categories of Interest
- Race / Ethnicity
- Age
- Geography
- Disability Status
- Access to Care
- Education Level
- Income Level
Data Set Used
Registered TierResearch Team
Owner:
- Jo-Hsuan Wu - Research Fellow, University of California, San Diego
- Sophia Sidhu - Graduate Trainee, University of California, San Diego
- Sally Baxter - Research Fellow, University of California, San Diego
- Bharanidharan Radha Saseendrakumar - Project Personnel, University of California, San Diego
Collaborators:
- Bonnie Huang - Graduate Trainee, Northwestern University
SDHA in Eye Conditions - v5 Dataset
Scientific Questions Being Studied
We are planning to explore disparities in healthcare access and utilization for patients with eye conditions across different demographic groups. We would like to evaluate risk of developing advanced/severe disease in different eye conditions, and understand how social determinants contribute to this risk while adjusting for other known risk factors. We are also interested in understanding the availability of social determinants of health data in this data repository compared to EHR clinical data warehouses alone.
Project Purpose(s)
- Population Health
Scientific Approaches
We will build cohorts of patients with various eye diseases (i.e. diabetic retinopathy, retinal vein occlusions, glaucoma, etc.). Then we will develop concept sets and extract data on outcomes (i.e. development of complications), as well as predictors including clinical data and social data. We will draw on survey data and EHR data within All of Us. When genomic data and wearable data become available, we are interested in evaluating those data sources as well. We will use statistical modeling and machine learning to generate predictive models.
Anticipated Findings
We anticipate that there may be differential risk for developing complications based on disparities in healthcare access and utilization for patients with eye conditions.
Demographic Categories of Interest
- Race / Ethnicity
- Age
- Geography
- Disability Status
- Access to Care
- Education Level
- Income Level
Data Set Used
Registered TierResearch Team
Owner:
- Terrence Lee - Graduate Trainee, University of California, San Diego
- Tonya Lee - Graduate Trainee, University of California, San Diego
- Sophia Sidhu - Graduate Trainee, University of California, San Diego
- Sally Baxter - Research Fellow, University of California, San Diego
- Kaela Acuff - Graduate Trainee, University of California, San Diego
- John McDermott - Graduate Trainee, University of California, San Diego
- Grace Ahn - Graduate Trainee, University of California, San Diego
- Gordon Ye - Undergraduate Student, University of California, San Diego
- Alison Chan - Graduate Trainee, University of California, San Diego
- Bita Shahrvini - Graduate Trainee, University of California, San Diego
- Bharanidharan Radha Saseendrakumar - Project Personnel, University of California, San Diego
- Arash Delavar - Graduate Trainee, University of California, San Diego
Collaborators:
- Francis Ratsimbazafy - Other, All of Us Program Operational Use
- Jun Qian - Other, All of Us Program Operational Use
- Joy Guo - Graduate Trainee, University of California, San Diego
- Bonnie Huang - Graduate Trainee, Northwestern University
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