James Pirruccello

Early Career Tenure-track Researcher, Mass General Brigham

1 active project

CarDB

We are trying to understand the risk factors for cardiovascular diseases (examples include cardiomyopathy, aortopathy, coronary artery disease, and arrhythmias). We are also trying to understand disease progression. In particular, we hope to assess the utility of externally derived predictors…

Scientific Questions Being Studied

We are trying to understand the risk factors for cardiovascular diseases (examples include cardiomyopathy, aortopathy, coronary artery disease, and arrhythmias). We are also trying to understand disease progression. In particular, we hope to assess the utility of externally derived predictors within the context of AllOfUs participants, and in some cases to be able to derive predictors in AllOfUs that can be tested externally (within the scope of what is permitted by the access agreement).

Project Purpose(s)

  • Disease Focused Research (Cardiovascular disease)
  • Ancestry

Scientific Approaches

We will use demographic information, biomarkers, imaging results where available, diagnostic codes, and human genetic data for risk modeling. When genetic data are available, we will also engage in genetic discovery and replication efforts for cardiovascular phenotypes and diseases.

Anticipated Findings

We anticipate validating cardiovascular risk scores for diverse populations within the United States; creating new risk scores; and discovering or replicating genetic findings for cardiovascular diseases.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Research Team

Owner:

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