Ayobami Akenroye

Graduate Trainee, Johns Hopkins University

1 active project

asthma biologic utilization

This research is to evaluate the real-world use, switches, and discontinuations of biologics in the treatment of asthma. Although 6 biologics are currently approved for asthma treatment, relatively little is known about their real-world use and effectiveness. Additionally, there is…

Scientific Questions Being Studied

This research is to evaluate the real-world use, switches, and discontinuations of biologics in the treatment of asthma. Although 6 biologics are currently approved for asthma treatment, relatively little is known about their real-world use and effectiveness. Additionally, there is some evidence that there may be inequitable use and access to these biologics. Furthermore, the patterns of use in individuals who are eligible for two or more of these biologics is currently unknown.

Project Purpose(s)

  • Disease Focused Research (asthma)

Scientific Approaches

Study population: individuals ≥18 years with diagnosis of asthma who were on any of the biologics approved for asthma treatment (omalizumab, benralizumab, mepolizumab, reslizumab, dupilumab) between 2005 to date. We will be using summary statistics in characterizing the incidence of initiation of these biologics, switches from one biologic to another (and when the switch occurred), and/or discontinuation. To evaluate if these switches were due to effectiveness of these biologics, we will evaluate asthma exacerbations while on the biologics. In addition, we will evaluate if these patterns differ by age, sex, or race and ethnicity.

Anticipated Findings

This study will improve our knowledge of real-world use and patterns of use of these biologics and can inform future studies and/or interventions in optimizing the benefits of these biologics.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Research Team

Owner:

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