Hasmin Ramirez

Project Personnel, National Institutes of Health (NIH)

2 active projects

Sickle Cell Trait Associated Clinical Outcomes

Sickle cell trait (SCT) is largely considered a benign carrier state; however, a growing body of research has found evidence on associated clinical complications. This analysis will build on our initial examination of the prevalence of clinical complications between SCT…

Scientific Questions Being Studied

Sickle cell trait (SCT) is largely considered a benign carrier state; however, a growing body of research has found evidence on associated clinical complications. This analysis will build on our initial examination of the prevalence of clinical complications between SCT and non-SCT carriers.
Our question is: Is there a prevalence of clinical complications among newly identified SCT carriers?

As our understanding of SCT continues to develop, accurately assessing possible related clinical complications and the factors that put carriers at higher risk of developing them will assist healthcare providers with counseling and treatment interventions for carriers.

Project Purpose(s)

  • Disease Focused Research (Sickle Cell Trait)
  • Ancestry

Scientific Approaches

In this study, individuals with sickle cell trait will be identified using genomic data. Electronic health records (EHRs) of identified SCT carriers will be analyzed to assess frequency of reported SCT associated clinical outcomes to help strengthen or refute current evidence on SCT association. High frequency of clinical outcomes with no reported association to SCT will also be accounted for.

Anticipated Findings

We anticipate that our findings will strengthen current evidence on the association of certain clinical outcomes with SCT. Overall, we hope that our findings will provide a better understanding of this carrier state, to improve genetic counseling and treatment for those living with sickle cell trait.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Data Set Used

Controlled Tier

Research Team

Owner:

  • Hasmin Ramirez - Project Personnel, National Institutes of Health (NIH)

Collaborators:

  • Faeben Wossenseged - Other, National Institutes of Health (NIH)

Sickle Cell Trait (SCT) Associated Clinical Outcomes

Sickle cell trait (SCT) is largely considered a benign carrier state; however, a growing body of research has found evidence on associated clinical complications. Our question is: What external and genetic factors increase the risk of developing clinical outcomes among…

Scientific Questions Being Studied

Sickle cell trait (SCT) is largely considered a benign carrier state; however, a growing body of research has found evidence on associated clinical complications. Our question is: What external and genetic factors increase the risk of developing clinical outcomes among SCT carriers? As our understanding of SCT continues to develop, accurately assessing possible related clinical complications and the factors that put carriers at higher risk of developing them will assist healthcare providers with counseling and treatment interventions for carriers.

Project Purpose(s)

  • Other Purpose (The primary purpose of this project is to identify differences in frequency of reported Sickle Cell Trait (SCT) associated clinical outcomes in a cohort of SCT and non-SCT carriers. In addition, this project aims to identify any external and genetic factors that may increase SCT-carriers’ risk of developing clinical outcomes. )

Scientific Approaches

In this study, electronic health records (EHRs) and surveys of identified SCT carriers will be analyzed to assess frequency of reported SCT associated clinical outcomes to help strengthen or refute current evidence on SCT association. High frequency of clinical outcomes with no reported association to SCT will also be accounted for. EHRs and surveys for a comparison group of All of Us participants that do not have SCT will also be assessed, to identify any significant differences in SCT associated clinical complication manifestation. Additionally, EHRs and surveys of both groups will be analyzed to determine history with external risk modifiers explored within SCT literature that may put carriers at higher risk of developing complications.

Anticipated Findings

We anticipate that our findings will strengthen current evidence on the association of certain clinical outcomes with SCT, as well as clarify the role of external factors in increasing the risk of developing complications. Overall, we hope that our findings will provide a better understanding of this carrier state, to improve genetic counseling and treatment for those living with sickle cell trait.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Data Set Used

Registered Tier

Research Team

Owner:

  • Hasmin Ramirez - Project Personnel, National Institutes of Health (NIH)

Collaborators:

  • Faeben Wossenseged - Other, National Institutes of Health (NIH)
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