Nyia Noel

Mid-career Tenured Researcher, Boston Medical Center

2 active projects

Uterine Fibroids

From this analysis, we hope to observe if there are differences in age, racial and risk distribution between both fibroids diagnostic cohorts. We also will determine the odds of this condition in both cohorts, based on modifiable risk factors such…

Scientific Questions Being Studied

From this analysis, we hope to observe if there are differences in age, racial and risk distribution between both fibroids diagnostic cohorts. We also will determine the odds of this condition in both cohorts, based on modifiable risk factors such as age, race and menopausal state and non-modifiable risk factors like obesity, use of hormones and smoking. These findings will be compared to findings from pre-existing data.

Project Purpose(s)

  • Disease Focused Research (Uterine Fibroids or Leiomyomas)
  • Population Health
  • Social / Behavioral
  • Methods Development
  • Other Purpose (“This work is a result of an All of Us Research Program Demonstration Project. The projects are efforts by the Program designed to meet the program's goal of ensuring the quality and utility of the Research Hub as a resource for accelerating discovery in science and medicine. This work was reviewed and overseen by the All of Us Research Program Science Committee and the Data and Research Center to ensure compliance with program policy, including policies for acceptable data access and use”.)

Scientific Approaches

Participants were eligible if they were assigned female sex at birth and had both Electronic Health Records (EHR) data and Patient Provided Information (PPI). Two fibroids cohorts were created based on:
1. Presence of at least one SNOMED code for uterine fibroids in their Electronic Health Records
2. Presence of one ICD-9 or CPT code for pelvic imaging (e.g., pelvic ultrasound) and one diagnostic code for uterine fibroids
Variables of interest were identified from the EHR and PPI and imported as concept sets into the notebook, otherwise they were created in the notebook. Data was analyzed in R software version 3.6.2, 2019.

Anticipated Findings

We anticipate that black females will have higher odds of fibroids compared to white women and that smokers will have lower odds of fibroids compared to non-smokers. While findings from this analysis are not novel, they validate existing knowledge and underscore the importance of the AoU data cohort in research. Furthermore, AoU cohort data represents females in the United States and Canada and, importantly, populations that are underrepresented in research.

Demographic Categories of Interest

  • Sex at Birth
  • Gender Identity
  • Sexual Orientation
  • Geography
  • Disability Status
  • Access to Care
  • Education Level
  • Income Level

Research Team

Owner:

  • Nyia Noel - Mid-career Tenured Researcher, Boston Medical Center

Collaborators:

  • Roxana Loperena Cortes - Other, All of Us Program Operational Use
  • Francis Ratsimbazafy - Other, All of Us Program Operational Use
  • Lizette Mendez - Project Personnel, Boston Medical Center
  • Confidence Achilike - Project Personnel, Boston Medical Center
  • Guohai Zhou - Other, Mass General Brigham

Breast Cancer

How breast cancer phentype in AoU

Scientific Questions Being Studied

How breast cancer phentype in AoU

Project Purpose(s)

  • Disease Focused Research (Breast Cancer)

Scientific Approaches

Not available.

Anticipated Findings

Phenotype

Demographic Categories of Interest

This study will not center on underrepresented populations.

Research Team

Owner:

  • Nyia Noel - Mid-career Tenured Researcher, Boston Medical Center
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