Chelsea Isom

University of California, San Diego

2 active projects

Chemoprevention in CRC and Breast Ca

Previous studies have shown that the drugs metformin, statins and aspirin all may have chemoprotective effects on cancer. However, other studies have shown that the effects are mitigated when other variables and accounted for. The research in animal models have…

Scientific Questions Being Studied

Previous studies have shown that the drugs metformin, statins and aspirin all may have chemoprotective effects on cancer. However, other studies have shown that the effects are mitigated when other variables and accounted for. The research in animal models have shown that there is a mechanistic reasoning behind the drug eliciting chemoprotective effects. Some studies have suggested that statins and metformin make work together to assert their effect. To date most of the studies have been in predominant population with European ancestry. Our primary goal is to determine if there is a chemoprotective effect seen with metformin, statins and aspirin. The secondary goal is to determine how these drugs in combination may change this relationship. These studies have predominant focused on colorectal and breast cancer.

Project Purpose(s)

  • Population Health

Scientific Approaches

For this study we will first determine if in the dataset we find any correlation between the drugs and prevention of colorectal or breast cancer. Then we plan to create a model to control for patient factors that may influence the relationship between the medication and cancer. Finally, we will create a model to determine how the medication may influence each other’s effect. To do this we will need to look at all patients that have electronic medical records data available. We will make a control set of adults that are 50 years old or older at the current time and have not taken metformin, statin or aspirin. We will then identify patients 50years old or older that have taken individually or in combination: metformin, statins and aspirin.

Anticipated Findings

We hope to find a positive correlation between the use of the medication and decreased cancer risk. This would contribute to the current literature because this study would be done on the most diverse population. This would add to the growing body of literature that these drugs may have chemoprotective effects.

Demographic Categories of Interest

  • Age

Research Team

Owner:

  • Laura Goetz - Early Career Tenure-track Researcher, Translational Genomics Research Institute
  • Chelsea Isom - Other, University of California, San Diego

Collaborators:

  • Francis Ratsimbazafy - Other, All of Us Program Operational Use

Breast Cancer Survivors COPE

Our focus is the effect of the COVID-19 pandemic and mitigation efforts on breast cancer survivors and potential differences with matched controls without a history of cancer based on responses to the COPE surveys to determine whether survivor status has…

Scientific Questions Being Studied

Our focus is the effect of the COVID-19 pandemic and mitigation efforts on breast cancer survivors and potential differences with matched controls without a history of cancer based on responses to the COPE surveys to determine whether survivor status has an influence on the experience of the pandemic in either positive or negative ways and to determine what factors (including socioeconomic or race/ethnicity) modify the experience. Specifically, we will: 1) Describe differences between breast cancer survivors and age- and ethnicity-matched controls without a history of cancer in responses to questions on: 1. Behaviors re: social distancing 2. Mental health 3. COVID symptoms, testing, treatment 4. Social isolation and 5. Health behaviors. Understanding specific effects of the pandemic on the mental health of breast cancer survivors will inform efforts to tailor interventions to reduce the negative effects of future similarly isolating events among this population.

Project Purpose(s)

  • Population Health
  • Social / Behavioral

Scientific Approaches

We will use the following AoURP datatsets:
• Basics survey: for demographics, including race/ethnicity, UBR status, gender and age
• COPE survey (May, June, July/August 2020, November 2020 and February 2021 )
• Electronic health records
We will use the statistical analysis tools in R to generate descriptive and appropriate inferential statistics.

Anticipated Findings

We expect to that we will find differences in the effects of the COVID-19 pandemic and mitigation efforts that will help understand factors associated with either increased resilience or increased negative effects among breast cancer survivors . We expect these findings to identify more targeted points of advocacy and allow a more focused approach in helping breast cancer survivors successfully cope with challenges posed by the pandemic.

Demographic Categories of Interest

  • Age

Research Team

Owner:

  • Jill Waalen - Mid-career Tenured Researcher, Scripps Research
  • Chelsea Isom - Other, University of California, San Diego
1 - 2 of 2
<
>
Request a Review of this Research Project

You can request that the All of Us Resource Access Board (RAB) review a research purpose description if you have concerns that this research project may stigmatize All of Us participants or violate the Data User Code of Conduct in some other way. To request a review, you must fill in a form, which you can access by selecting ‘request a review’ below.