Humberto López Castillo

Early Career Tenure-track Researcher, University of Central Florida

2 active projects

Ethnicity Disparities in Acute Myocardial Infarction in PLWH

Research Question: This moderation analysis study will denote the influence of a third variable, Ethnicity (Moderator), on the relationship between CD4+ cell count (predictor 1) and viral load (predictor 2) and AMI (the outcome). The data needed for the statistical…

Scientific Questions Being Studied

Research Question: This moderation analysis study will denote the influence of a third variable, Ethnicity (Moderator), on the relationship between CD4+ cell count (predictor 1) and viral load (predictor 2) and AMI (the outcome). The data needed for the statistical interpretation will be collected from the NIH-sponsored All of Us database.
CVD in the US is a significant threat, holding the title as the number one killer in America, disproportionately affecting minority communities. PLWH are more drastically affected by the implications of CVD and are at a significantly higher risk. Although a causal relationship exists between low CD4 cell count and AMI, the potential moderation effect of ethnicity has not been studied in this population.

Project Purpose(s)

  • Population Health

Scientific Approaches

Study participants will be 18 years of age or older and have a diagnosis of HIV infection. The following variables will be extracted for all study participants, as these pertain to the research hypotheses:
• Hispanic ethnicity (moderator)
• Most recent CD4 count (predictor)
• Most recent viral load (predictor)
• History of acute myocardial infarction (outcome)
Additionally, demographic variables (i.e., Race, Sex at birth, Gender identity, Birthplace, Annual income, Health insurance) will be extracted to ensure comparability among study groups.

Anticipated Findings

We hypothesize that:
1. There is a strong association between the predictors (CD4 count and viral load) and AMI outcomes.
2. Hispanic ethnicity this expected association, we anticipate a higher OR for Hispanic PLWH.

Demographic Categories of Interest

  • Race / Ethnicity

Data Set Used

Registered Tier

Research Team

Owner:

Cardiovascular Disease in MSM

This study will retrospectively analyze disparities in indicators of cardiovascular disease (i.e., hypertension, type 2 diabetes mellitus, obesity, dyslipidemias, stroke, and inflammatory biomarkers) and risk and protective factors (i.e., smoking, alcohol use, physical activity, diet, access to healthcare, drug use,…

Scientific Questions Being Studied

This study will retrospectively analyze disparities in indicators of cardiovascular disease (i.e., hypertension, type 2 diabetes mellitus, obesity, dyslipidemias, stroke, and inflammatory biomarkers) and risk and protective factors (i.e., smoking, alcohol use, physical activity, diet, access to healthcare, drug use, intimate partner violence, sex work) among sexual minority individuals registered in the “All of Us” Database.

Project Purpose(s)

  • Population Health
  • Educational

Scientific Approaches

We will identify prevalence rates of indicators of cardiovascular disease among the population of interest using frequencies. We will model outcomes using regression methods.

Anticipated Findings

We anticipate that MSM will present with higher prevalence of cardiovascular outcomes, given the minority stress components.

Demographic Categories of Interest

  • Sexual Orientation
  • Education Level
  • Income Level

Data Set Used

Registered Tier

Research Team

Owner:

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