Ismael Lugo

Graduate Trainee, San Juan Bautista School of Medicine

1 active project

AD in Hispanics and association with ACE polymorphisms

This project looks to answer if there is an association between genetic variants rs4343 and rs4351 of the angiotensin-converting enzyme (ACE) gene and Alzheimers disease (AD) among Hispanic persons. Using the All of Us data, our study will evaluate the…

Scientific Questions Being Studied

This project looks to answer if there is an association between genetic variants rs4343 and rs4351 of the angiotensin-converting enzyme (ACE) gene and
Alzheimers disease (AD) among Hispanic persons. Using the All of Us data, our study will evaluate the association of ACE gene polymorphism with AD risk factors in this minoritized group. Our central hypothesis is that ACE gene polymorphism in Hispanics will be associated with AD and can be used as an AD risk factor to assess the risk of Hispanic persons for this disease clinically.

Project Purpose(s)

  • Disease Focused Research (Alzheimers Disease)
  • Educational
  • Ancestry

Scientific Approaches

We plan to use data regarding surveys completed by participants in the All of Us platform as well as other documented information from these patients in order to do tables and graphs with the program R studio, in order to compare outcomes and associations between these groups and Alzheimers Disease.

Anticipated Findings

Finding new genes associated with alzheimers disease in a minority community will help early on detection, prevention and management of the disease.

Demographic Categories of Interest

  • Race / Ethnicity
  • Age

Data Set Used

Registered Tier

Research Team

Owner:

  • Ismael Lugo - Graduate Trainee, San Juan Bautista School of Medicine
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