Yingchang Lu
Early Career Tenure-track Researcher, Vanderbilt University Medical Center
2 active projects
Heart Disease AllofUs WGS analysis
Scientific Questions Being Studied
The incidence of coronary artery disease in populations of African ancestry is higher than that in populations of European ancestry. Besides the social economic risk factors, behavior risk factors, and access to health care, the genetic factors may underlie the observed this health disparity. Hundreds of genetic loci have been identified in genome-wide association studies of coronary artery disease in populations of European ancestry and populations of Eastern Asian ancestry. However, very few loci were identified in populations of African ancestry. This may create the hurdles of equal utilization of precision medicine in control and prevention of coronary artery disease across populations. We will perform the large genome-wide association study of coronary artery disease in populations of African ancestry.
Project Purpose(s)
- Disease Focused Research (coronary artery disease)
- Ancestry
Scientific Approaches
We will perform a whole genome sequence analysis of coronary artery disease with allofus electronic health record data.
Anticipated Findings
We will identify genetic loci associated with coronary artery diseases in populations of African ancestry that shared with populations of other ancestries or are unique to populations of African ancestry due to its unique demographic and evolutionary history. The novel biology elucidated from the identified loci will help with the control and prevention of coronary artery disease across all populations.
Demographic Categories of Interest
- Race / Ethnicity
Data Set Used
Controlled TierResearch Team
Owner:
- Yingchang Lu - Early Career Tenure-track Researcher, Vanderbilt University Medical Center
Duplicate of Phenotype - Ischemic Heart Disease (v7)
Scientific Questions Being Studied
The Notebooks in this workspace can be used to implement well-known phenotype algorithms in one’s own research.
Project Purpose(s)
- Educational
- Methods Development
- Other Purpose (This is an All of Us Phenotype Library Workspace created by the Researcher Workbench Support team. It is meant to demonstrate the implementation of key phenotype algorithms within the All of Us Research Program cohort.)
Scientific Approaches
Not Applicable
Anticipated Findings
By reading and running the Notebooks in this Phenotype Library Workspace, researchers can implement the following phenotype algorithms:
Christianne L. Roumie; Jana Shirey-Rice, Sunil Kripalani. Vanderbilt University. MidSouth CDRN - Coronary Heart Disease Algorithm. PheKB; 2014. Available from https://phekb.org/phenotype/234
Demographic Categories of Interest
This study will not center on underrepresented populations.
Data Set Used
Registered TierResearch Team
Owner:
- Yingchang Lu - Early Career Tenure-track Researcher, Vanderbilt University Medical Center
Request a Review of this Research Project
You can request that the All of Us Resource Access Board (RAB) review a research purpose description if you have concerns that this research project may stigmatize All of Us participants or violate the Data User Code of Conduct in some other way. To request a review, you must fill in a form, which you can access by selecting ‘request a review’ below.
