Hsueh-Han Yeh

Research Associate, Henry Ford Health System

9 active projects

AmyTang-MS_new-D27

Objective: Determine the prevalence, demographics and regional distribution of multiple sclerosis (MS) in the All of Us Research Program?

Scientific Questions Being Studied

Objective: Determine the prevalence, demographics and regional distribution of multiple sclerosis (MS) in the All of Us Research Program?

Project Purpose(s)

  • Disease Focused Research (multiple sclerosis)
  • Other Purpose (Provide evidence of AOU ability to replicate findings on the prevalence and demographics of MS)

Scientific Approaches

Study population: All of Us Research Program participants who have given access to their electronic health record information and who have answered the Basics survey, and who have answered Personal Medical History survey. Data analysis: We will determine the prevalence of multiple sclerosis in the All of Us Research Program electronic medical record data and personal medical history survey with three different cohorts: patients had EHR only, survey only and both EHR and Survey. Those data will then be stratified by age, sex, race/ethnicity and region as self-reported in the Basics PPI survey.

Anticipated Findings

We anticipate that the AoURP will have prevalence and demographics of MS as recent previous studies. We further anticipate that findings regarding MS in AoURP participants' EHR will be similar to those in the survey data.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Data Set Used

Registered Tier

Research Team

Owner:

Duplicate of D015-housing

What is the prevalence of housing insecurity among current participants in the All of Us study? What individual-level factors are related to housing insecurity, including demographics, indicators of health care access, and perceived health status?

Scientific Questions Being Studied

What is the prevalence of housing insecurity among current participants in the All of Us study? What individual-level factors are related to housing insecurity, including demographics, indicators of health care access, and perceived health status?

Project Purpose(s)

  • Population Health
  • Other Purpose (The data can provide evidence of AOU ability to replicate findings around social determinants and the ability to identify vulnerable populations in our cohort.)

Scientific Approaches

We will determine the prevalence of housing insecurity in the All of Us study sample using data collected in the Basics module (“worried or concerned about not having a place to live”). We will use housing insecurity as the dependent variable in a multivariate analysis to determine the relationship of healthcare access and health services utilization. Finally, we will report the independent relationship between housing insecurity and healthcare access, adjusting for the covariates and conducting stratified analyses as appropriate.

Anticipated Findings

Recently, investigators examined the relationship of housing insecurity using the 2011-2015 BRFSS and found a 12.6% prevalence among the >228,000 in the study sample. All of Us can replicate these findings among its core participants using questionnaire items similar to those used by investigators.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Data Set Used

Registered Tier

Research Team

Owner:

  • Hsueh-Han Yeh - Research Associate, Henry Ford Health System
  • Xiaoqin Tang - Early Career Tenure-track Researcher, Henry Ford Health System

MS_new-D27

Objective: Determine the prevalence, demographics and regional distribution of multiple sclerosis (MS) in the All of Us Research Program?

Scientific Questions Being Studied

Objective: Determine the prevalence, demographics and regional distribution of multiple sclerosis (MS) in the All of Us Research Program?

Project Purpose(s)

  • Disease Focused Research (multiple sclerosis)
  • Other Purpose (Provide evidence of AOU ability to replicate findings on the prevalence and demographics of MS)

Scientific Approaches

Study population: All of Us Research Program participants who have given access to their electronic health record information and who have answered the Basics survey, and who have answered Personal Medical History survey. Data analysis: We will determine the prevalence of multiple sclerosis in the All of Us Research Program electronic medical record data and personal medical history survey with three different cohorts: patients had EHR only, survey only and both EHR and Survey. Those data will then be stratified by age, sex, race/ethnicity and region as self-reported in the Basics PPI survey.

Anticipated Findings

We anticipate that the AoURP will have prevalence and demographics of MS as recent previous studies. We further anticipate that findings regarding MS in AoURP participants' EHR will be similar to those in the survey data.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Data Set Used

Registered Tier

Research Team

Owner:

  • Hsueh-Han Yeh - Research Associate, Henry Ford Health System
  • Xiaoqin Tang - Early Career Tenure-track Researcher, Henry Ford Health System

MS project

Prevalence of MS in US Change overtime Demographic characteristics Geographic location Demography by location

Scientific Questions Being Studied

Prevalence of MS in US
Change overtime
Demographic characteristics
Geographic location
Demography by location

Project Purpose(s)

  • Disease Focused Research (multiple sclerosis)

Scientific Approaches

Multiple sclerosis is the most common progressive neurologic disease of young adults worldwide. Recently, studies have found not only an increased prevalence of MS within the US population but also increased prevalence in females, certain age groups, racial/ethnic groups and geographic regions. The All of Us Research Program gives us the ability to replicate these findings among its participants using diagnoses of multiple sclerosis in electronic medical records as well as information provided in PPI surveys. This analysis can provide evidence of AOU ability to replicate findings on the prevalence and demographics of MS as well as determine if multiple sclerosis patients (or certain demographics of those with multiple sclerosis, such as racial/ethnic minorities) are overrepresented in the cohort. This will be a exploratory study. We will use simple rate calculation and logistic regression.

Anticipated Findings

We are trying to answer these research questions:
What is the prevalence of multiple sclerosis (MS) in the All of Us Research Program? What are the demographics of All of Us participants with MS?
What US census region has the highest prevalence of MS?

Demographic Categories of Interest

This study will not center on underrepresented populations.

Data Set Used

Registered Tier

Research Team

Owner:

NewTry-COPE

To investigate how COVID pandemic affect individual's mental health and how do people cope with it, and the results from this study will help the public and mental health professionals better understand the people's mental health during pandemic.

Scientific Questions Being Studied

To investigate how COVID pandemic affect individual's mental health and how do people cope with it, and the results from this study will help the public and mental health professionals better understand the people's mental health during pandemic.

Project Purpose(s)

  • Population Health

Scientific Approaches

Plan to use COPE dataset, other survey data and EHR data for this study. This will be a retrospective study design by using logistic regression or difference-in-difference method to study diagnosis of mental health before and after pandemic between individuals with and without mental health diagnoses before pandemic.

Anticipated Findings

We anticipate to see pandemic impact individuals' wellbeing differently for those with mental health versus those without.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Data Set Used

Registered Tier

Research Team

Owner:

New - COPE-Anxiety

To investigate how COVID pandemic affect individual's mental health and how do people cope with it, and the results from this study will help the public and mental health professionals better understand the people's mental health during pandemic.

Scientific Questions Being Studied

To investigate how COVID pandemic affect individual's mental health and how do people cope with it, and the results from this study will help the public and mental health professionals better understand the people's mental health during pandemic.

Project Purpose(s)

  • Population Health

Scientific Approaches

Plan to use COPE dataset, other survey data and EHR data for this study. This will be a retrospective study design by using logistic regression or difference-in-difference method to study diagnosis of mental health before and after pandemic between individuals with and without mental health diagnoses before pandemic.

Anticipated Findings

We anticipate to see pandemic impact individuals' wellbeing differently for those with mental health versus those without.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Data Set Used

Registered Tier

Research Team

Owner:

Collaborators:

  • Gage Rion - Project Personnel, All of Us Program Operational Use
  • Aymone Kouame - Other, All of Us Program Operational Use

New D014 - Opioids

As a demonstration project, this study will present the results of prevalence of opioid use in the United States. Specific questions include: 1. What is the prevalence of prescription opioids received from healthcare systems? 2. What is the prevalence of…

Scientific Questions Being Studied

As a demonstration project, this study will present the results of prevalence of opioid use in the United States. Specific questions include:

1. What is the prevalence of prescription opioids received from healthcare systems?
2. What is the prevalence of opioids misuse including nonmedical prescription opioids use and street opioid use?
3. Data in both previous questions will also be stratified by geographic region

Project Purpose(s)

  • Other Purpose (This work is a result of an All of Us Research Program Demonstration Project. The projects are efforts by the Program designed to meet the program's goal of ensuring the quality and utility of the Research Hub as a resource for accelerating discovery in science and medicine. This work was reviewed and overseen by the All of Us Research Program Science Committee and the Data and Research Center to ensure compliance with program policy, including policies for acceptable data access and use.)

Scientific Approaches

We will identify prevalence of opioid use in two ways and stratified by state.
First, we use EHR Drug Exposures to capture use of prescription opioid.
Second, we use lifestyle survey questionnaire to capture substance use reported by patients themselves:
1. In your LIFETIME, which of the following substances have you ever used?
2. In the PAST THREE MONTHS, how often have you used this substance?
The prevalence will be stratified by state, therefore EHR Observation Table will be used to capture this information.

Anticipated Findings

For this study, we anticipate that we will be able to replicate previous national studies of estimating prevalence of opioids. All of Us workbench research data also provides an alternative tool for assessing prevalence rate of substance use and prescription opioids for US population.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Data Set Used

Registered Tier

Research Team

Owner:

Duplicate of D014 - Opioids

As a demonstration project, this study will present the results of prevalence of opioid use in the United States. Specific questions include: 1. What is the prevalence of prescription opioids received from healthcare systems? 2. What is the prevalence of…

Scientific Questions Being Studied

As a demonstration project, this study will present the results of prevalence of opioid use in the United States. Specific questions include:

1. What is the prevalence of prescription opioids received from healthcare systems?
2. What is the prevalence of opioids misuse including nonmedical prescription opioids use and street opioid use?
3. Data in both previous questions will also be stratified by geographic region

Project Purpose(s)

  • Other Purpose (This work is a result of an All of Us Research Program Demonstration Project. The projects are efforts by the Program designed to meet the program's goal of ensuring the quality and utility of the Research Hub as a resource for accelerating discovery in science and medicine. This work was reviewed and overseen by the All of Us Research Program Science Committee and the Data and Research Center to ensure compliance with program policy, including policies for acceptable data access and use.)

Scientific Approaches

We will identify prevalence of opioid use in two ways and stratified by state.
First, we use EHR Drug Exposures to capture use of prescription opioid.
Second, we use lifestyle survey questionnaire to capture substance use reported by patients themselves:
1. In your LIFETIME, which of the following substances have you ever used?
2. In the PAST THREE MONTHS, how often have you used this substance?
The prevalence will be stratified by state, therefore EHR Observation Table will be used to capture this information.

Anticipated Findings

For this study, we anticipate that we will be able to replicate previous national studies of estimating prevalence of opioids. All of Us workbench research data also provides an alternative tool for assessing prevalence rate of substance use and prescription opioids for US population.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Data Set Used

Registered Tier

Research Team

Owner:

  • Hsueh-Han Yeh - Research Associate, Henry Ford Health System
  • Jun Qian - Other, All of Us Program Operational Use
  • Ashley Able - Other, All of Us Program Operational Use

COPE-Anxiety

To investigate how COVID pandemic affect individual's mental health and how do people cope with it, and the results from this study will help the public and mental health professionals better understand the people's mental health during pandemic.

Scientific Questions Being Studied

To investigate how COVID pandemic affect individual's mental health and how do people cope with it, and the results from this study will help the public and mental health professionals better understand the people's mental health during pandemic.

Project Purpose(s)

  • Population Health

Scientific Approaches

Plan to use COPE dataset, other survey data and EHR data for this study. This will be a retrospective study design by using logistic regression or difference-in-difference method to study diagnosis of mental health before and after pandemic between individuals with and without mental health diagnoses before pandemic.

Anticipated Findings

We anticipate to see pandemic impact individuals' wellbeing differently for those with mental health versus those without.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Data Set Used

Registered Tier

Research Team

Owner:

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