Elisabeth Rosenthal

Project Personnel, University of Washington

1 active project

Calculate CRC PRS

We are developing trans-ethnic polygenic risk scores (PRS) for colorectal cancer (CRC). We want to observe and compare the distribution of the PRS in different ancestries, using the genetic data from participants in AllofUs. Using this information, we may be…

Scientific Questions Being Studied

We are developing trans-ethnic polygenic risk scores (PRS) for colorectal cancer (CRC). We want to observe and compare the distribution of the PRS in different ancestries, using the genetic data from participants in AllofUs. Using this information, we may be able to adjust the scores for ancestry groups (Normalize) so that the PRS is comparable across ancestries and provides the same clinical benefits across ancestries.

Project Purpose(s)

  • Methods Development

Scientific Approaches

We plan to use the AllofUs genotype array data. We will attempt to impute fine scale genotypes genome-wide and then calculate the CRC PRS for each participant. We will also perform principal components of ancestry to determine ancestries for each participant. We plan to use R, the Michigan Imputatation Server, TopMed reference genotype data, and 1000 genomes reference genotype data.

Anticipated Findings

We plan to calculate mean and standard deviation of the PRS within ancestries. We will use this information to adjust PRS values so that they are comparable across ancestries and have similiar clinical utility across ancestries.

Demographic Categories of Interest

  • Race / Ethnicity
  • Age

Research Team

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