University of Pittsburgh
1 active project
HIV and viral hepatitis
Scientific Questions Being Studied
HIV and viral hepatitides, especially hepatitis B virus (HBV) and hepatitis C virus (HCV) infection are causing significant global health burdens. HIV, HBV and HCV are characterized by overlapping modes of transmission. Despite this shared route, research and interventions often focus on these diseases independently, leading to missed opportunities for comprehensive care and prevention strategies.
Aim 1. To evaluate the prevalence of HBV and HCV infection in people with HIV (PWH).
Aim 2. To evaluate risk factors associated with viral hepatitides co-infection.
Aim 3. To evaluate care gaps in PWH, especially lack of viral hepatitis screening, vaccinations and treatment of viral hepatitides.
Aim 4. To understand morbidities and mortalities in PWH with viral hepatitides co-infection.
- Disease Focused Research (viral infectious disease)
For Aim 1, we plan to evaluate the temporal trend of viral hepatitides rate in PWH. We lack contemporary data on HIV-viral hepatitides co-infection landscape, especially in the era of HCV direct-acting antiviral (DAA) and highly-effective dual HIV-HBV-active antiretroviral therapy (ART). We would consider having either all HIV-negative group and/or propensity-matched HIV-negative group as comparator.
For Aim 2, we would use propensity-matched HIV-negative group (match for age group, race, ethnicity, education levels etc. ) to explore factors associated with co-infection, especially social determinants.
For Aim 3, we want to look at availability of viral serology data, liver ultrasound data, and vaccination record, as well as HIV-related care metrics in people with and without viral hepatitides co-infection.
For Aim 4, we would like to explore morbidities and mortalities related to liver and non-liver diseases.
We anticipate the following results and more importantly, learn from this study:
1. Yearly trend in viral hepatitides co-infection prevalence and incidence.
2. Identify social determinants that are associated with co-infection diagnosis, and more importantly, delay in diagnosis, gaps in cares, and gaps in treatment.
3. To understand morbidities and mortalities related to liver and non-liver diseases in HIV-viral hepatitides co-infected population, especially in the era of DAA, dual-active ART, and more importantly, COVID-19 pandemics.
Demographic Categories of Interest
This study will not center on underrepresented populations.
Data Set UsedControlled Tier
- Yijia Li - Other, University of Pittsburgh
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