Meleeka Akbarpour

Graduate Trainee, University of California, Irvine

1 active project

Sex Differences in CVD Comorbidities & Risk Factors based on COVID-19 Positivity

Our study will look at how cardiovascular disease comorbidities, risk factors, and behaviors differ by sex in those who are COVID-19 positive versus negative. This question is important because there is a lack of public knowledge on the association between…

Scientific Questions Being Studied

Our study will look at how cardiovascular disease comorbidities, risk factors, and behaviors differ by sex in those who are COVID-19 positive versus negative. This question is important because there is a lack of public knowledge on the association between COVID-19 and cardiovascular health and how this may differ between men and women. Therefore, we are interested in analyzing prevalent cardiovascular comorbidities, risk factors, and behaviors according to COVID-19 test positivity. Since there are some sex differences in COVID-19 outcomes, we wish to examine how comorbidities, risk factors, and behaviors may differ between men and women.

Project Purpose(s)

  • Disease Focused Research (COVID-19, cardiovascular disease, hypertension, diabetes, heart failure)

Scientific Approaches

We will use the cohort builder to find participants who tested positive for COVID-19. Our inclusion criteria will include cardiovascular risk factors, behaviors and comorbidities. Our exclusion criteria will include people who tested negative for COVID-19. We will then create a second cohort of participants who have tested negative for COVID-19. Our inclusion criteria will remain the same as the first cohort, but this time the exclusion criteria will include people who tested positive for COVID-19. We will also stratify our cohorts into male versus female. After, we will create a dataset builder, and generate concept sets on cardiovascular risk factors (eg hypertension, blood pressure, diabetes, obesity), behaviors (diet, smoking, physical activity), and comorbidities (prior history of coronary heart disease, stroke, heart failure, COPD, diabetes). We will then import the data to Jupyter Notebook and write code in R to analyze our data.

Anticipated Findings

The anticipated findings from this study are that males who tested positive for COVID-19 will have the most cardiovascular risk factors, followed by males who tested negative for COVID-19, females who tested positive for COVID-19, and lastly, females who tested negative for COVID-19. We expect that males who tested positive for COVID-19 will be more likely to have hypertension, diabetes and less physical activity compared to females. Our findings will be useful to those who have contracted COVID-19 during this pandemic, and how they may be at risk for developing new or aggravating current cardiovascular conditions.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Research Team

Owner:

Collaborators:

  • Yufan Gong - Graduate Trainee, University of California, Los Angeles
  • Nathan Wong - Other, University of California, Irvine
  • Divya Devineni - Graduate Trainee, University of California, Irvine
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