Jun Qian

All of Us Program Operational Use

2 active projects

Duplicate of D014 - Opioids

As a demonstration project, this study will present the results of prevalence of opioid use in the United States. Specific questions include: 1. What is the prevalence of prescription opioids received from healthcare systems? 2. What is the prevalence of…

Scientific Questions Being Studied

As a demonstration project, this study will present the results of prevalence of opioid use in the United States. Specific questions include:

1. What is the prevalence of prescription opioids received from healthcare systems?
2. What is the prevalence of opioids misuse including nonmedical prescription opioids use and street opioid use?
3. Data in both previous questions will also be stratified by geographic region

Project Purpose(s)

  • Other Purpose (This work is a result of an All of Us Research Program Demonstration Project. The projects are efforts by the Program designed to meet the program's goal of ensuring the quality and utility of the Research Hub as a resource for accelerating discovery in science and medicine. This work was reviewed and overseen by the All of Us Research Program Science Committee and the Data and Research Center to ensure compliance with program policy, including policies for acceptable data access and use.)

Scientific Approaches

We will identify prevalence of opioid use in two ways and stratified by state.
First, we use EHR Drug Exposures to capture use of prescription opioid.
Second, we use lifestyle survey questionnaire to capture substance use reported by patients themselves:
1. In your LIFETIME, which of the following substances have you ever used?
2. In the PAST THREE MONTHS, how often have you used this substance?
The prevalence will be stratified by state, therefore EHR Observation Table will be used to capture this information.

Anticipated Findings

For this study, we anticipate that we will be able to replicate previous national studies of estimating prevalence of opioids. All of Us workbench research data also provides an alternative tool for assessing prevalence rate of substance use and prescription opioids for US population.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Research Team

Owner:

  • Hsueh-Han Yeh - Research Associate, Henry Ford Health System
  • Jun Qian - Other, All of Us Program Operational Use
  • Ashley Able - Other, Vanderbilt University Medical Center

Duplicate of AFib epidemiology

The overall goal of this study, as a Demonstration project, is to evaluate the ability of the All of Us Research Program data to replicate epidemiologic patterns of atrial fibrillation (AF), a common arrhythmia, previously described in other setting. We…

Scientific Questions Being Studied

The overall goal of this study, as a Demonstration project, is to evaluate the ability of the All of Us Research Program data to replicate epidemiologic patterns of atrial fibrillation (AF), a common arrhythmia, previously described in other setting. We will address this goal with these two aims:
• Specific Aim 1. To determine the association of race and ethnicity with the prevalence and incidence of atrial fibrillation (AF). We hypothesize than non-whites will have lower prevalence and incidence of AF than whites.
• Specific Aim 2. To estimate associations of established risk factors for AF with the prevalence and incidence of AF. We hypothesize that increased body mass index, higher blood pressure, diabetes, smoking and a prior history of cardiovascular diseases will be associated with increased prevalence and incidence of AF.

Project Purpose(s)

  • Population Health
  • Other Purpose (This work is a result of an All of Us Research Program Demonstration Project. The projects are efforts by the Program designed to meet the program's goal of ensuring the quality and utility of the Research Hub as a resource for accelerating discovery in science and medicine. This work was reviewed and overseen by the All of Us Research Program Science Committee and the Data and Research Center to ensure compliance with program policy, including policies for acceptable data access and use.)

Scientific Approaches

We will select all All of Us participants who self-reported sex at birth male or female, whose self-reported race was white, black or Asian, as well as those who self-reported being Hispanics.

Atrial fibrillation (AF) will be identified from self-reports in the medical survey or from electronic health records (EHR).

Clinical factors will be identified from EHR and study measurements (blood pressure, weight, height).

We will evaluate the association of demographic (age, sex, race/ethnicity) and clinical (body mass index, blood pressure, smoking, cardiovascular diseases) factors with prevalence of self-reported AF and prevalence of AF in the EHR, as well as incident AF ascertained from the EHR.

Anticipated Findings

The overall goal of this project is to evaluate the prevalence and incidence of atrial fibrillation (AF), overall and by race/ethnicity, as well as to confirm the association of established risk factors for AF in the All of Us Research participants. We expect to confirm associations between demographic and clinical variables previously reported in the literature, demonstrating the value of the All of Us Research Program data to address questions regarding this common cardiovascular disease.

Demographic Categories of Interest

  • Race / Ethnicity
  • Age

Research Team

Owner:

  • Jun Qian - Other, All of Us Program Operational Use
  • Ashley Able - Other, Vanderbilt University Medical Center
  • Alvaro Alonso - Late Career Tenured Researcher, Emory University
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