Edward Preble

Senior Researcher, All of Us Researcher Academy/RTI International

1 active project

AIM-AHEAD - SDOH Impact on Comorbid Osteoporosis in Breast Cancer

We will use the breast cancer phenotype as an example for studying SDOH variables using the Controlled Tier Curated Data Repository (CDR). We will investigate if SDOH factors are associated with comorbid osteoporosis in breast cancer.

Scientific Questions Being Studied

We will use the breast cancer phenotype as an example for studying SDOH variables using the Controlled Tier Curated Data Repository (CDR). We will investigate if SDOH factors are associated with comorbid osteoporosis in breast cancer.

Project Purpose(s)

  • Educational
  • Other Purpose (This workspace will be used as part of the AIM-AHEAD initiative as one example of analysis that can be conducted within All of Us. It is intended to demonstrate how to build a cohort with disparate data sources that can be used to check for associations between outcomes (e.g., comorbid osteoporosis) and SDOH variables.)

Scientific Approaches

We will start with a cohort of breast cancer patients with SDOH information available. We will characterize the SDOH factors and compare them to breast cancer and osteoporosis comorbidity. We will quantify the associations through statistical methods while controlling for demographics and other factors.

Anticipated Findings

This workspace should provide an example of a complete analysis, from cohort identification through insight generation, within All of Us. The breast cancer phenotype is based on work done by Ning Shang, George Hripcsak, Chunhua Weng, Wendy K. Chung, & Katherine Crew (originally retrieved from https://phekb.org/phenotype/breast-cancer).

Demographic Categories of Interest

This study will not center on underrepresented populations.

Data Set Used

Controlled Tier

Research Team

Owner:

  • Michael Long - Senior Researcher, All of Us Researcher Academy/RTI International
  • Daniel Brannock - Senior Researcher, All of Us Researcher Academy/RTI International
  • Jonathan Holt - Research Associate, All of Us Researcher Academy/RTI International
  • John McCarthy - Project Personnel, All of Us Researcher Academy/RTI International
  • Edward Preble - Senior Researcher, All of Us Researcher Academy/RTI International

Collaborators:

  • Trey-Rashad Hawkins - Project Personnel, All of Us Researcher Academy/RTI International
  • Stefanee Tillman - Project Personnel, All of Us Researcher Academy/RTI International
  • Kristin Glaze - Project Personnel, All of Us Researcher Academy/RTI International
  • Javan Carter - Research Associate, All of Us Researcher Academy/RTI International
  • Angela Gasdaska - Teacher/Instructor/Professor, All of Us Researcher Academy/RTI International
  • Andrew Burnette - Administrator, All of Us Researcher Academy/RTI International
  • Zahra Rahemi - Early Career Tenure-track Researcher, Clemson University
  • Youjeong Kang - Early Career Tenure-track Researcher, Emory University
  • Yaritza Inostroza-Nieves - Early Career Tenure-track Researcher, San Juan Bautista School of Medicine
  • Wesley Godfrey - Graduate Trainee, Johns Hopkins University
  • Vincenzo Malo - Project Personnel, All of Us Researcher Academy/RTI International
  • Laleh Jalilian - Mid-career Tenured Researcher, University of California, Los Angeles
  • Tadesse Abegaz - Graduate Trainee, Florida A&M University
  • Sonya Dave - Research Associate, Washington University in St. Louis
  • Robin Zhao - Undergraduate Student, Cornell University
  • Oyomoare Osazuwa-Peters - Other, Duke University
  • Melody Schiaffino - Other, University of California, San Diego
  • Monica Ochapa - Graduate Trainee, Morgan State University
  • Mia Campbell - Graduate Trainee, Johns Hopkins University
  • Michael Ortega - Early Career Tenure-track Researcher, University of Hawaii at Manoa
  • Lyndee Ward - Graduate Trainee, University of North Texas Health Science Center
  • Luis Alvarado - Research Fellow, University of Louisville
  • LaKeta Kemp - Graduate Trainee, Howard University
  • Atiya Shahid - Graduate Trainee, Tuskegee University
  • Jonathan Kim - Graduate Trainee, Arizona State University
  • Steven Golob - Graduate Trainee, University of Washington
  • Anita Esquerra-Zwiers - Mid-career Tenured Researcher, Hope College
  • Emily Bear - Project Personnel, So'oh-Shinálí Sister Project
  • Shayla Williams - Mid-career Tenured Researcher, Albany State University
  • Cecily Byrne - Research Fellow, University of Illinois at Chicago
  • Christian Cazares - Research Fellow, University of California, San Diego
  • Alaysia Brown - Research Fellow, Harvard Faculty of Arts and Sciences
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