Joshua Routh
Early Career Tenure-track Researcher, Midwestern University
2 active projects
CHIP controlled
Scientific Questions Being Studied
I am exploring the data to support the development of a biomarker to identify clonal hematopoiesis of indeterminate potential (CHIP), a premalignant blood disorder associated with increased risk of malignancy and cardiovascular disease. I would like to determine the health effects of CHIP including the risk of developing benign and malignant disease.
Project Purpose(s)
- Disease Focused Research (Clonal Hematopoiesis)
- Methods Development
Scientific Approaches
I will seek to identify patients with somatic alterations in the genes, TET2, DNMT2A, JAK2, TP53 and a handful of other associated genes to create a disease cohort. I will create a control population from other individuals in the dataset by selecting controls with matching age, sex, and other factors. The case control series will be analyzed to characterize the risks associated with CHIP.
Anticipated Findings
We believe that we will confirm the findings of pervious studies showing increased risk of heart disease, stroke and hematolymphoid malignancy. Additionally, we may identify novel disease associations. This large dataset may allow us to control for confounding factors and isolate CHIP as a variable. Independent confirmation of CHIP's risk associations for heart disease and stroke in this dataset will support the conclusions of previous studies. Any new disease associations identified by this study will implicate clonal hematopoiesis in the pathogenesis and direct further research.
Demographic Categories of Interest
This study will not center on underrepresented populations.
Data Set Used
Controlled Tier
CHIP explore
Scientific Questions Being Studied
I am exploring the data to support the development of a biomarker to identify clonal hematopoiesis of indeterminate potential (CHIP), a premalignant blood disorder associated with increased risk of malignancy and cardiovascular disease. I would like to determine the health effects of CHIP including the risk of developing benign and malignant disease.
Project Purpose(s)
- Disease Focused Research (Clonal Hematopoiesis )
- Educational
- Methods Development
Scientific Approaches
I will seek to identify patients with somatic alterations in the genes, TET2, DNMT2A, JAK2, TP53 and a handful of other associated genes to create a disease cohort. I will create a control population from other individuals in the dataset by selecting controls with matching age, sex, and other factors. The case control series will be analyzed to characterize the risks associated with CHIP.
Anticipated Findings
We believe that we will confirm the findings of pervious studies showing increased risk of heart disease, stroke and hematolymphoid malignancy. Additionally, we may identify novel disease associations. This large dataset may allow us to control for confounding factors and isolate CHIP as a variable. Independent confirmation of CHIP's risk associations for heart disease and stroke in this dataset will support the conclusions of previous studies. Any new disease associations identified by this study will implicate clonal hematopoiesis in the pathogenesis and direct further research.
Demographic Categories of Interest
This study will not center on underrepresented populations.
Data Set Used
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