Michelle Yau

Research Associate, Hebrew SeniorLife

1 active project

Drug repurposing for osteoarthritis

There is a great need for new drug development for osteoarthritis (OA). Some drugs and biologics already in use to treat other conditions may be effective for OA. Identifying which of these already approved drugs may have effects on OA…

Scientific Questions Being Studied

There is a great need for new drug development for osteoarthritis (OA). Some drugs and biologics already in use to treat other conditions may be effective for OA. Identifying which of these already approved drugs may have effects on OA can help reduce the cost and time needed for development of new OA therapies. Our study aims to identify one or more promising treatments for OA by assessing whether certain drug classes may have effects on OA in a large, diverse dataset.

Project Purpose(s)

  • Disease Focused Research (osteoarthritis)
  • Ancestry

Scientific Approaches

We plan to use drug epidemiology approaches to determine whether certain drug classes affect OA. When genetic data are available, we will use Mendelian randomization approaches to determine whether variation in genes that mimic the effects of these drug classes are associated with OA.

Anticipated Findings

Our study will provide insights into new drug classes that may be repurposed for OA. We anticipate that our findings will help accelerate drug development for OA by identifying promising new drug targets that can be used for future development of OA therapeutics.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Research Team

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