Graduate Trainee, University of Minnesota
1 active project
Scientific Questions Being Studied
What causes microscopic hematuria? In pediatric patients, one of the most common known causes is Alport syndrome, caused by a mutation in a gene required for extracellular matrix (ECM) integrity. Another more recent discovery showed that a different gene that is also required for ECM integrity causes hematuria if mutated. This study will try to identify other genes that are required for the ECM function and determine if any are associated with hematuria. Discovering the specific cause hematuria can help determine the best treatment for patients rather than treating all cases of hematuria the same without knowing the root cause.
- Disease Focused Research (Microscopic Hematuria)
To determine genes associated with microscopic hematuria, this project will focus in on patients with persistent microscopic hematuria without Alport syndrome. All ECM genes will be analyzed and mutations identified. The rate of mutations for these genes will be compared to that of a control population with similar history and characteristics to determine if any of the genes have a higher percentage of mutation compared to the control population.
I anticipate that other ECM genes such as agrins or proteins needed for glycosylation will be identified. This will open new avenues for researchers to study the roles of these proteins and how mutations may contribute to disease.
Demographic Categories of Interest
This study will not center on underrepresented populations.
Data Set UsedControlled Tier
- Michael Anderson - Graduate Trainee, University of Minnesota
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