James Crim

Graduate Trainee, George Washington University

2 active projects

BACKUP Feb 12 2024 Comorbidity of Substance Use and

Substance use and chronic physical conditions (chronic pain, liver diseases, and diabetes) are highly comorbid. Genetic and environmental influences on their comorbidity have not been elucidated. To inform clinical efforts, it is important to examine the shared etiological mechanisms underlying…

Scientific Questions Being Studied

Substance use and chronic physical conditions (chronic pain, liver diseases, and diabetes) are highly comorbid. Genetic and environmental influences on their comorbidity have not been elucidated. To inform clinical efforts, it is important to examine the shared etiological mechanisms underlying their comorbidity.

Project Purpose(s)

  • Disease Focused Research (substance use disorder and chronic pain conditions)
  • Population Health
  • Social / Behavioral
  • Ancestry
  • Other Purpose (Ancestry)

Scientific Approaches

Genome-wide association studies of substance use- and chronic physical conditions (chronic pain, liver diseases, and diabetes)-related phenotypes will be conducted, genetic associations among the phenotypes will be estimated, and functional analyses will be performed. Contextual moderators will be modeled in the analyses.

Anticipated Findings

Identify biological mechanisms underlying the comorbidity of substance use and chronic physical conditions (chronic pain, liver diseases, and diabetes), and the contextual factors that modify the relations between genetics and the comorbidity.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Data Set Used

Controlled Tier

Research Team

Owner:

  • James Crim - Graduate Trainee, George Washington University

BACKUP (Jan 22 2024) OF Comorbidity of Substance Use and Chronic Phy

Substance use and chronic physical conditions (chronic pain, liver diseases, and diabetes) are highly comorbid. Genetic and environmental influences on their comorbidity have not been elucidated. To inform clinical efforts, it is important to examine the shared etiological mechanisms underlying…

Scientific Questions Being Studied

Substance use and chronic physical conditions (chronic pain, liver diseases, and diabetes) are highly comorbid. Genetic and environmental influences on their comorbidity have not been elucidated. To inform clinical efforts, it is important to examine the shared etiological mechanisms underlying their comorbidity.

Project Purpose(s)

  • Disease Focused Research (substance use disorder and chronic pain conditions)
  • Population Health
  • Social / Behavioral
  • Ancestry
  • Other Purpose (Ancestry)

Scientific Approaches

Genome-wide association studies of substance use- and chronic physical conditions (chronic pain, liver diseases, and diabetes)-related phenotypes will be conducted, genetic associations among the phenotypes will be estimated, and functional analyses will be performed. Contextual moderators will be modeled in the analyses.

Anticipated Findings

Identify biological mechanisms underlying the comorbidity of substance use and chronic physical conditions (chronic pain, liver diseases, and diabetes), and the contextual factors that modify the relations between genetics and the comorbidity.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Data Set Used

Controlled Tier

Research Team

Owner:

  • James Crim - Graduate Trainee, George Washington University
1 - 2 of 2
<
>
Request a Review of this Research Project

You can request that the All of Us Resource Access Board (RAB) review a research purpose description if you have concerns that this research project may stigmatize All of Us participants or violate the Data User Code of Conduct in some other way. To request a review, you must fill in a form, which you can access by selecting ‘request a review’ below.