Project Personnel, All of Us Researcher Academy/RTI International
1 active project
RTI Type I Diabetes PRS Validation Analysis
Scientific Questions Being Studied
Based on the research done from the Sharp et. al. 2019 paper and the Qu et. al. paper, Polygenic Risk Scores (PRS's) were developed for European and African biological and ancestral groups. We would like to go and validate the PRS's against and independent cohort of individuals associated with Type I Diabetes to recalculate the PRS threshold using the all of us database. Additionally, we want to further validate the PRS's against other biological ancestral races such as East Asian and Hispanic.
- Disease Focused Research (type 1 diabetes mellitus)
- Methods Development
- Control Set
Create cohorts representing individuals with Type I Diabetes from various backgrounds and races based off of PTA ancestral predictions and run a customized PRS calculation script on the candidate PRS markers described in Qu et. al., 2022.
The anticipated findings for the study could either be confirming that all 72 PRS candidate markers are sufficient across multiple ancestral populations, or that confoundment plays a role in the overall effect size of the PRS markers for given or specific ancestral populations, thus requiring new thresholds to be established for different ancestral populations, other than European.
Demographic Categories of Interest
- Race / Ethnicity
Data Set UsedControlled Tier
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