Kristin Glaze

Project Personnel, All of Us Researcher Academy/RTI International

2 active projects

DUPLICATE: RTI Research Academy R Workshop (Sickle Cell Project)

This workbench is designed to be used as an educational tool for the RTI Research academy. Therefore, there isn't a scientific question that will be explored. The pseudo- question is associated with Sickle cell and how to identify it using…

Scientific Questions Being Studied

This workbench is designed to be used as an educational tool for the RTI Research academy. Therefore, there isn't a scientific question that will be explored. The pseudo- question is associated with Sickle cell and how to identify it using GWAS. The target audience are students, graduate students, post-docs, and PIs from HBCUs (Historically Black Community Colleges/ Universities). The goal is the reduce the gap of knowledge between HBCUs and PWI and give HBCUs the tools and confidence to use the AoU workbench.

Project Purpose(s)

  • Educational

Scientific Approaches

We will be creating a cohort of individuals with the sickle cell disease and those who do not (control). This cohort will be converted into a dataset and processed in the R notebook. We will be using PLINK as a genotyping and GWAS tool. The overall goal is "education without intimidation". We want to introduce these topics to our students in the most parsimonious way with high accuracy and correctness to remove the fluff and allow the student to feel comfortable with the knowledge presented.

Anticipated Findings

There are no anticipated findings because of the nature of the project. This study will ultimately contribute to the scientific knowledge by advancing the knowledge of the individuals who take the course and eventually start their own amazing research study.

Demographic Categories of Interest

  • Race / Ethnicity

Data Set Used

Controlled Tier

Research Team

Owner:

  • Vincenzo Malo - Project Personnel, All of Us Researcher Academy/RTI International
  • Trey-Rashad Hawkins - Project Personnel, All of Us Researcher Academy/RTI International
  • Stefanee Tillman - Project Personnel, All of Us Researcher Academy/RTI International
  • Kristin Glaze - Project Personnel, All of Us Researcher Academy/RTI International
  • Javan Carter - Research Associate, All of Us Researcher Academy/RTI International

RTI Type I Diabetes PRS Validation Analysis

Based on the research done from the Sharp et. al. 2019 paper and the Qu et. al. paper, Polygenic Risk Scores (PRS's) were developed for European and African biological and ancestral groups. We would like to go and validate the…

Scientific Questions Being Studied

Based on the research done from the Sharp et. al. 2019 paper and the Qu et. al. paper, Polygenic Risk Scores (PRS's) were developed for European and African biological and ancestral groups. We would like to go and validate the PRS's against and independent cohort of individuals associated with Type I Diabetes to recalculate the PRS threshold using the all of us database. Additionally, we want to further validate the PRS's against other biological ancestral races such as East Asian and Hispanic.

Project Purpose(s)

  • Disease Focused Research (type 1 diabetes mellitus)
  • Methods Development
  • Control Set
  • Ancestry

Scientific Approaches

Create cohorts representing individuals with Type I Diabetes from various backgrounds and races based off of PTA ancestral predictions and run a customized PRS calculation script on the candidate PRS markers described in Qu et. al., 2022.

Anticipated Findings

The anticipated findings for the study could either be confirming that all 72 PRS candidate markers are sufficient across multiple ancestral populations, or that confoundment plays a role in the overall effect size of the PRS markers for given or specific ancestral populations, thus requiring new thresholds to be established for different ancestral populations, other than European.

Demographic Categories of Interest

  • Race / Ethnicity

Data Set Used

Controlled Tier

Research Team

Owner:

  • Kristin Glaze - Project Personnel, All of Us Researcher Academy/RTI International
  • Javan Carter - Research Associate, All of Us Researcher Academy/RTI International
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