Research Projects Directory

Research Projects Directory

At this time, all listed projects are using data in the registered tier. The registered tier contains individual-level data from electronic health records, survey answers, and physical measurements. These data have been altered to protect participant privacy.

Note: Researcher Workbench users provide information about their research projects independently. Any views expressed in the Research Projects Directory belong to the relevant users and do not necessarily represent those of the All of Us Research Program.

Information in the Research Projects Directory is also cross-posted on AllofUs.nih.gov in compliance with the 21st Century Cures Act.

There are currently 214 active workspaces. This information was updated on 9/23/2020.

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Vitamin B12 deficiency and supplementation in patients on metformin

Project Purpose(s)

  • Disease Focused Research (type 2 diabetes mellitus)
  • Population Health ...

Scientific Questions Being Studied

1. What proportion of patients with type 2 diabetes who take metformin have a vitamin B 12 deficiency?
2. What proportion of patients with type 2 diabetes who take metformin have had their vitamin B 12 levels measured?
3. What proportion of patients with type 2 diabetes who take metformin and have a vitamin B 12 deficiency are taking vitamin B 12 supplement?
4. Are there demographic or other disparities between patients with type 2 diabetes who take metformin and have vitamin B 12 deficiency compared with those who do not have deficiency?
5. Are there demographic or other disparities between patients with type 2 diabetes who take metformin and have had their vitamin B 12 levels measured compared with those who have not had it measured?
6. Are there demographic or other disparities between patients with type 2 diabetes who take metformin, have a vitamin B 12 deficiency and take vitamin B 12 supplement compared with those who do not take vitamin B 12 supplement?

Scientific Approaches

Data will be drawn from EHR domains (diagnosis of type 2 diabetes, use of metformin, vitamin B 12 levels, vitamin B 12 supplementation), and survey responses (demographics, healthcare access and utilization). Basic descriptive statistics will be used to answer questions 1-3 above and inferential statistics to assess for disparities based on demographic factors, etc. (questions 4-6).

Anticipated Findings

This work will contribute to our understanding of how common vitamin B 12 deficiency is in patients who take metformin. Additionally, how likely it is patients taking metformin will be tested for deficiency and how likely it is that deficiency will be treated if present. Finally, this work aims to assess disparities, whether they be gender/sex-based, racial/ethnic, socioeconomic (e.g. educational attainment, income), age-based, or others, in the likelihood a patient taking metformin will have their vitamin B 12 levels assessed, whether they will have a deficiency and whether a deficiency will be treated if it is present.

Demographic Categories of Interest

  • Race / Ethnicity
  • Age
  • Gender Identity
  • Geography
  • Access to Care
  • Education Level
  • Income Level

Research Team

Owner:

  • Keri Hurley-Kim - Other, University of California, Irvine

Warfarin

Project Purpose(s)

  • Educational
  • Drug Development ...
  • Ancestry

Scientific Questions Being Studied

I am exploring the data to see what is possible to explore regarding warfarin dose and diet. I hope to be able to find new associations in dietary indices that explain warfarin dose in a prediction model.

Scientific Approaches

This is an exploratory workbench and I will be using mainly visualizations and summary statistics of potential covariates.

Anticipated Findings

This is an exploratory workbench. Potential associations with warfarin dose may be added to dose prediction models in the future.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Research Team

Owner:

  • Heidi Steiner - Graduate Trainee, University of Arizona

Warfarin ABO

Project Purpose(s)

  • Population Health ...

Scientific Questions Being Studied

We will investigate the frequency of warfarin dose tablet sizes in ABO blood groups. O blood type has been associated with higher warfarin doses.

Scientific Approaches

We will use the drug exposure warfarin and ABO blood groups in order to test the proportion of higher tablet dosage, and therefore dose, in different blood types.

Anticipated Findings

We anticipate to find blood types have disparately distributed warfarin tablet dosages. Blood type could be an easily implementable prediction variable in warfarin dose prediction algorithms.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Research Team

Owner:

  • Heidi Steiner - Graduate Trainee, University of Arizona