Research Projects Directory

Research Projects Directory

2,583 active projects

This information was updated 9/26/2022

The Research Projects Directory includes information about all projects that currently exist in the Researcher Workbench to help provide transparency about how the Workbench is being used. Each project specifies whether Registered Tier or Controlled Tier data are used.

Note: Researcher Workbench users provide information about their research projects independently. Views expressed in the Research Projects Directory belong to the relevant users and do not necessarily represent those of the All of Us Research Program. Information in the Research Projects Directory is also cross-posted on AllofUs.nih.gov in compliance with the 21st Century Cures Act.

1 project has 'Identifying mechanisms of alcohol use risk among sexual minority intersections' in the project title
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Identifying mechanisms of alcohol use risk among sexual minority intersections

Sexual minority communities are up to 3 times more likely to have a lifetime substance use disorder, yet individual differences and processes of risk remain unclear. Identifying for whom and why substance use and/or disorder risk is greatest within this…

Scientific Questions Being Studied

Sexual minority communities are up to 3 times more likely to have a lifetime substance use disorder, yet individual differences and processes of risk remain unclear. Identifying for whom and why substance use and/or disorder risk is greatest within this specialized population is essential in informing potential intervention targets for remitting SUD across sexual orientation groups. This project proposes using the All of Us dataset for developing and obtaining a training grant that addresses moderators and mediators of substance use risk among sexual minority subpopulations.

Project Purpose(s)

  • Population Health
  • Social / Behavioral
  • Methods Development

Scientific Approaches

This project proposes the development and application of novel data mining methods for identifying moderators and mechanisms of SM SUD risk leveraging several large and diverse longitudinal samples of young adult SMs, including the All of Us data resource. In particular, we intend on using regularized regression, classification and regression trees, and exploratory mediation strategies for pursuing our hypotheses. In contrast to conventional regression-based approaches, these data mining methods are better able to handle high-dimensional data scenarios that are representative of the complex hypotheses we hope to test (e.g., models with multiple interacting variables, sparse data conditions, and multiple candidate mediators). All analyses will be conducted using open-source and well-vetted R packages.

Anticipated Findings

The goals of this study are to 1) identify to what degree specific intersecting identities (e.g., sexual and racial minority men and women) confer greater alcohol and other substance use risk, and 2) delineate the specific causal mechanisms (e.g., minority identity-related stressors) unique to these intersections that explain heightened within-person substance use risk among these populations. This research will aid in translating intersectional and sexual minority stress theories into actionable research addressing the heterogeneity of substance use prevention and intervention among at-risk SM populations. Identifying these intersectional phenotypes and their mechanisms of substance use risk will advance the precision medicine of substance use disorder while promoting equity in the prevention and intervention of alcohol- and substance-related disease.

Demographic Categories of Interest

  • Race / Ethnicity
  • Age
  • Sexual Orientation
  • Education Level
  • Income Level

Data Set Used

Registered Tier

Research Team

Owner:

  • Connor McCabe - Research Fellow, University of California, San Diego
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Request a Review of this Research Project

You can request that the All of Us Resource Access Board (RAB) review a research purpose description if you have concerns that this research project may stigmatize All of Us participants or violate the Data User Code of Conduct in some other way. To request a review, you must fill in a form, which you can access by selecting ‘request a review’ below.