Research Projects Directory

Research Projects Directory

5,357 active projects

This information was updated 6/7/2023

The Research Projects Directory includes information about all projects that currently exist in the Researcher Workbench to help provide transparency about how the Workbench is being used. Each project specifies whether Registered Tier or Controlled Tier data are used.

Note: Researcher Workbench users provide information about their research projects independently. Views expressed in the Research Projects Directory belong to the relevant users and do not necessarily represent those of the All of Us Research Program. Information in the Research Projects Directory is also cross-posted on AllofUs.nih.gov in compliance with the 21st Century Cures Act.

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Demo - Pharmacogenomics (PGx) variant frequency and medication exposures

1) How common are actionable PGx variants among the diverse participants of different genetic ancestry in AoURP? 2) What percentage of AoU participants are prescribed drugs with PGx prescribing recommendations? Which of these drugs are most common? 3) How often…

Scientific Questions Being Studied

1) How common are actionable PGx variants among the diverse participants of different genetic ancestry in AoURP?
2) What percentage of AoU participants are prescribed drugs with PGx prescribing recommendations? Which of these drugs are most common?
3) How often do participants have gene-drug interactions defined as an actionable phenotype and an exposure to a medication with PGx recommendations. How often will AoU participants receive AoU "DNA and your medication" PGx reports that are relevant to them personally (based on genetic data and prior medication use)?

Project Purpose(s)

  • Methods Development
  • Ancestry
  • Other Purpose (This work is a result of an All of Us Research Program Demonstration Project. The projects are efforts by the Program designed to meet the program's goal of ensuring the quality and utility of the Research Hub as a resource for accelerating discovery in science and medicine. This work was reviewed and overseen by the All of Us Research Program Science Committee and the Data and Research Center to ensure compliance with program policy, including policies for acceptable data access and use.)

Scientific Approaches

We will assess the AoU variant data for the presence of specific alleles and predicted phenotypes known to be associated with adverse drug reactions or altered dosage recommendations. These data will be also be stratified by genetic ancestry for comparison to gnomAD and CPIC published frequencies. In parallel, frequency of medication exposures to drugs with pharmacogenomic recommendations (CPIC and FDA) will be determined from electronic health record data. Finally, the intersection of these data will provide for estimates of potential utility of pharmacogenomic data among AoURP participants by evaluating gene-predicted phenotype-medication exposures.

Anticipated Findings

We expect these data will show the a potential high impact of PGx broadly and across diverse groups. We expect frequencies to be similar to prior published analyses from academic health systems, gnomAD, and CPIC provide the opportunity for comparison. Genetics ancestry groups will provide data on the frequencies in diverse populations. The data will also be useful for guiding AoU internally regarding the impact of return of results (RoR) for PGx genes currently approved for return (under our IDE) as well as those considered for future addition. This can steer expectations of participant engagement and RoR processes.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Data Set Used

Controlled Tier

Research Team

Owner:

  • Philip Empey - Mid-career Tenured Researcher, University of Pittsburgh

Collaborators:

  • Andrew Haddad - Graduate Trainee, University of Pittsburgh
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